Annulation of Thioimidates and Vinyl Carbodiimides to Prepare 2-Aminopyrimidines, Competent Nucleophiles for Intramolecular Alkyne Hydroamination. Synthesis of (−)-Crambidine

par Perl, Nicholas R., Ide, Nathan D., Prajapati, Sudeep, Perfect, Hahdi H., Durón, Sergio G., Gin, David Y.
Publié 2010

Design and Synthesis of Potent Quillaja Saponin Vaccine Adjuvants

par Adams, Michelle M., Damani, Payal, Perl, Nicholas R., Won, Annie, Hong, Feng, Livingston, Philip O., Ragupathi, Govind, Gin, David Y.
Publié 2010

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes

par Ge, Pei, Navarro, Iris D., Kessler, Marco M., Bernier, Sylvie G., Perl, Nicholas R., Sarno, Renee, Masferrer, Jaime, Hannig, Gerhard, Stamer, W. Daniel
Publié dans Invest Ophthalmol Vis Sci (2016)

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

par Nakai, Takashi, Perl, Nicholas R., Barden, Timothy C., Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J., Jin, Hong, Kim, Charles, Lee, Thomas W.-H., Long, Kimberly, Moore, Joel, Rohde, Jason M., Sarno, Renee, Segal, Chrissie, Solberg, Erik O., Tobin, Jenny, Zimmer, Daniel P., Currie, Mark G.
Publié dans ACS Med Chem Lett (2016)

Discovery of IWP-051, a novel orally bioavailable soluble guanylate cyclase stimulator with sustained and dose-dependent hemodynamic effects

par Nakai, Takashi, Perl, Nicholas R, Iyengar, Rajesh R, Mermerian, Ara, Im, G-Yoon J, Lee, Thomas W-H, Rennie, Glen R, Jia, James, Renhowe, Paul A, Barden, Timothy C, Sheppeck, James E, Iyer, Karthik, Jung, Joon, Milne, G Todd, Segal, Chrissie, Long, Kimberly, Miyashiro, Joy, Bernier, Sylvie, Jacobson, Sarah, Tobin, Jenny, Shea, Courtney, Germano, Peter, Chien, Yueh-tyng, Zimmer, Daniel
Publié dans BMC Pharmacol Toxicol (2015)