Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

[Image: see text] In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases associated with fibrosis and end-organ failure. Herein, we describe our design and synthesis of a series of 4-hydroxypyrimi...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Nakai, Takashi, Perl, Nicholas R., Barden, Timothy C., Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J., Jin, Hong, Kim, Charles, Lee, Thomas W.-H., Long, Kimberly, Moore, Joel, Rohde, Jason M., Sarno, Renee, Segal, Chrissie, Solberg, Erik O., Tobin, Jenny, Zimmer, Daniel P., Currie, Mark G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867485/
https://ncbi.nlm.nih.gov/pubmed/27190594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00479
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