The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes

PURPOSE: The nitric oxide (NO)–cyclic guanosine-3′,5′-monophosphate (cGMP) pathway regulates aqueous humor outflow and therefore, intraocular pressure. We investigated the pharmacologic effects of the soluble guanylate cyclase (sGC) stimulator IWP-953 on primary human trabecular meshwork (HTM) cells...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Ge, Pei, Navarro, Iris D., Kessler, Marco M., Bernier, Sylvie G., Perl, Nicholas R., Sarno, Renee, Masferrer, Jaime, Hannig, Gerhard, Stamer, W. Daniel
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2016
Subjects:
Physiology and Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811179/
https://ncbi.nlm.nih.gov/pubmed/26998718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-18958
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