Annulation of Thioimidates and Vinyl Carbodiimides to Prepare 2-Aminopyrimidines, Competent Nucleophiles for Intramolecular Alkyne Hydroamination. Synthesis of (−)-Crambidine

af Perl, Nicholas R., Ide, Nathan D., Prajapati, Sudeep, Perfect, Hahdi H., Durón, Sergio G., Gin, David Y.
Udgivet 2010

Design and Synthesis of Potent Quillaja Saponin Vaccine Adjuvants

af Adams, Michelle M., Damani, Payal, Perl, Nicholas R., Won, Annie, Hong, Feng, Livingston, Philip O., Ragupathi, Govind, Gin, David Y.
Udgivet 2010

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes

af Ge, Pei, Navarro, Iris D., Kessler, Marco M., Bernier, Sylvie G., Perl, Nicholas R., Sarno, Renee, Masferrer, Jaime, Hannig, Gerhard, Stamer, W. Daniel
Udgivet i Invest Ophthalmol Vis Sci (2016)

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

af Nakai, Takashi, Perl, Nicholas R., Barden, Timothy C., Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J., Jin, Hong, Kim, Charles, Lee, Thomas W.-H., Long, Kimberly, Moore, Joel, Rohde, Jason M., Sarno, Renee, Segal, Chrissie, Solberg, Erik O., Tobin, Jenny, Zimmer, Daniel P., Currie, Mark G.
Udgivet i ACS Med Chem Lett (2016)

Discovery of IWP-051, a novel orally bioavailable soluble guanylate cyclase stimulator with sustained and dose-dependent hemodynamic effects

af Nakai, Takashi, Perl, Nicholas R, Iyengar, Rajesh R, Mermerian, Ara, Im, G-Yoon J, Lee, Thomas W-H, Rennie, Glen R, Jia, James, Renhowe, Paul A, Barden, Timothy C, Sheppeck, James E, Iyer, Karthik, Jung, Joon, Milne, G Todd, Segal, Chrissie, Long, Kimberly, Miyashiro, Joy, Bernier, Sylvie, Jacobson, Sarah, Tobin, Jenny, Shea, Courtney, Germano, Peter, Chien, Yueh-tyng, Zimmer, Daniel
Udgivet i BMC Pharmacol Toxicol (2015)