Molecular imaging probe development: a chemistry perspective

Tekijä Nolting, Donald D, Nickels, Michael L, Guo, Ning, Pham, Wellington
Julkaistu 2012

New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO

Tekijä Li, Jun, Schulte, Michael L., Nickels, Michael L., Manning, H. Charles
Julkaisussa Bioorg Med Chem Lett (2016)

Automated Radiosynthesis of 5-[(11)C]L-Glutamine, an Important Tracer for Glutamine Utilization

Tekijä Rosenberg, Adam J., Nickels, Michael L., Schulte, Michael L., Manning, H. Charles
Julkaisussa Nucl Med Biol (2018)

Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazino...

Tekijä Cheung, Yiu-Yin, Nickels, Michael L., Tang, Dewei, Buck, Jason R., Manning, H. Charles
Julkaistu 2014

Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([(18)F]VUIIS1008) in...

Tekijä Tang, Dewei, Nickels, Michael L., Tantawy, M. Noor, Buck, Jason R., Manning, H. Charles
Julkaisussa Mol Imaging Biol (2014)

Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[(18)F]Fluoroethoxy) phenyl)-5-Methylpyrazolo[1,5-a] Pyrimidin-3-yl)-N,N-Diethylacetamide ((18)F-VUIIS1018A) to...

Tekijä Tang, Dewei, Li, Jun, Nickels, Michael L., Huang, Gang, Cohen, Allison S., Manning, H. Charles
Julkaisussa Mol Imaging Biol (2019)

High-yielding, automated production of 3′-deoxy-3′-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module

Tekijä Cheung, Yiu-Yin, Nickels, Michael L., McKinley, Eliot T., Buck, Jason R., Manning, H. Charles
Julkaisussa Appl Radiat Isot (2014)

N-[(18)F]-Fluoroacetylcrizotinib: A Potentially Potent and Selective PET Tracer for Molecular Imaging of Non–small Cell Lung Cancer

Tekijä Buck, Jason R., Saleh, Samir, Claus, Trey, Lovly, Christine, Hight, Matthew R., Nickels, Michael L., Tantawy, M. Noor, Manning, H. Charles
Julkaisussa Bioorg Med Chem Lett (2020)

Evaluation of TSPO PET Ligands [(18)F]VUIIS1009A and [(18)F]VUIIS1009B: Tracers for Cancer Imaging

Tekijä Tang, Dewei, Li, Jun, Buck, Jason R., Tantawy, Mohamed Noor, Xia, Yan, Harp, Joel M., Nickels, Michael L., Meiler, Jens, Manning, H. Charles
Julkaisussa Mol Imaging Biol (2017)

Synthesis and Structure-Activity Relationships of 5,6,7-substituted Pyrazolopyrimidines: Discovery of a novel TSPO PET Ligand for Cancer Imaging

Tekijä Tang, Dewei, McKinley, Eliot T., Hight, Matthew R., Uddin, Md. Imam, Harp, Joel M., Fu, Allie, Nickels, Michael L., Buck, Jason R., Manning, H. Charles
Julkaistu 2013

Preclinical Evaluation of 4-[(18)F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer

Tekijä Hassanein, Mohamed, Hight, Matthew R., Buck, Jason R., Tantawy, Mohammed N., Nickels, Michael L., Hoeksema, Megan D., Harris, Bradford K., Boyd, Kelli, Massion, Pierre P., Manning, H. Charles
Julkaisussa Mol Imaging Biol (2016)

A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells

Tekijä Hight, Matthew R., Cheung, Yiu-Yin, Nickels, Michael L., Dawson, Eric S., Zhao, Ping, Saleh, Samir, Buck, Jason R., Tang, Dewei, Washington, M. Kay, Coffey, Robert J., Manning, H. Charles
Julkaistu 2014

Utility of [(18)F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population

Tekijä Kavanaugh, Gina, Williams, Jason, Morris, Andrew Scott, Nickels, Michael L., Walker, Ronald, Koglin, Norman, Stephens, Andrew W., Washington, M. Kay, Geevarghese, Sunil K., Liu, Qi, Ayers, Dan, Shyr, Yu, Manning, H. Charles
Julkaisussa Mol Imaging Biol (2016)

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

Tekijä Luo, Na, Nixon, Mellissa J., Gonzalez-Ericsson, Paula I., Sanchez, Violeta, Opalenik, Susan R., Li, Huili, Zahnow, Cynthia A., Nickels, Michael L., Liu, Fei, Tantawy, Mohammed N., Sanders, Melinda E., Manning, H. Charles, Balko, Justin M.
Julkaisussa Nat Commun (2018)

Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults

Tekijä Smith, Christopher T., San Juan, M. Danica, Dang, Linh C., Katz, Daniel T., Perkins, Scott F., Burgess, Leah L., Cowan, Ronald L., Manning, H. Charles, Nickels, Michael L., Claassen, Daniel O., Samanez-Larkin, Gregory R., Zald, David H.
Julkaisussa Transl Psychiatry (2018)

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer

Tekijä Uddin, Md. Jashim, Wilson, Andrew J., Crews, Brenda C., Malerba, Paola, Uddin, Md. Imam, Kingsley, Philip J., Ghebreselasie, Kebreab, Daniel, Cristina K., Nickels, Michael L., Tantawy, Mohammed N., Jashim, Elma, Manning, H. Charles, Khabele, Dineo, Marnett, Lawrence J.
Julkaisussa ACS Omega (2019)

Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models

Tekijä Schulte, Michael L., Fu, Allie, Zhao, Ping, Li, Jun, Geng, Ling, Smith, Shannon T., Kondo, Jumpei, Coffey, Robert J., Johnson, Marc O., Rathmell, Jeffrey C., Sharick, Joe T., Skala, Melissa C., Smith, Jarrod A., Berlin, Jordan, Washington, M. Kay, Nickels, Michael L., Manning, H. Charles
Julkaisussa Nat Med (2018)