Molecular imaging probe development: a chemistry perspective

by Nolting, Donald D, Nickels, Michael L, Guo, Ning, Pham, Wellington
Published 2012

New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO

by Li, Jun, Schulte, Michael L., Nickels, Michael L., Manning, H. Charles
Published in Bioorg Med Chem Lett (2016)

Automated Radiosynthesis of 5-[(11)C]L-Glutamine, an Important Tracer for Glutamine Utilization

by Rosenberg, Adam J., Nickels, Michael L., Schulte, Michael L., Manning, H. Charles
Published in Nucl Med Biol (2018)

Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazino...

by Cheung, Yiu-Yin, Nickels, Michael L., Tang, Dewei, Buck, Jason R., Manning, H. Charles
Published 2014

Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([(18)F]VUIIS1008) in...

by Tang, Dewei, Nickels, Michael L., Tantawy, M. Noor, Buck, Jason R., Manning, H. Charles
Published in Mol Imaging Biol (2014)

Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[(18)F]Fluoroethoxy) phenyl)-5-Methylpyrazolo[1,5-a] Pyrimidin-3-yl)-N,N-Diethylacetamide ((18)F-VUIIS1018A) to...

by Tang, Dewei, Li, Jun, Nickels, Michael L., Huang, Gang, Cohen, Allison S., Manning, H. Charles
Published in Mol Imaging Biol (2019)

High-yielding, automated production of 3′-deoxy-3′-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module

by Cheung, Yiu-Yin, Nickels, Michael L., McKinley, Eliot T., Buck, Jason R., Manning, H. Charles
Published in Appl Radiat Isot (2014)

N-[(18)F]-Fluoroacetylcrizotinib: A Potentially Potent and Selective PET Tracer for Molecular Imaging of Non–small Cell Lung Cancer

by Buck, Jason R., Saleh, Samir, Claus, Trey, Lovly, Christine, Hight, Matthew R., Nickels, Michael L., Tantawy, M. Noor, Manning, H. Charles
Published in Bioorg Med Chem Lett (2020)

Evaluation of TSPO PET Ligands [(18)F]VUIIS1009A and [(18)F]VUIIS1009B: Tracers for Cancer Imaging

by Tang, Dewei, Li, Jun, Buck, Jason R., Tantawy, Mohamed Noor, Xia, Yan, Harp, Joel M., Nickels, Michael L., Meiler, Jens, Manning, H. Charles
Published in Mol Imaging Biol (2017)

Synthesis and Structure-Activity Relationships of 5,6,7-substituted Pyrazolopyrimidines: Discovery of a novel TSPO PET Ligand for Cancer Imaging

by Tang, Dewei, McKinley, Eliot T., Hight, Matthew R., Uddin, Md. Imam, Harp, Joel M., Fu, Allie, Nickels, Michael L., Buck, Jason R., Manning, H. Charles
Published 2013

Preclinical Evaluation of 4-[(18)F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer

by Hassanein, Mohamed, Hight, Matthew R., Buck, Jason R., Tantawy, Mohammed N., Nickels, Michael L., Hoeksema, Megan D., Harris, Bradford K., Boyd, Kelli, Massion, Pierre P., Manning, H. Charles
Published in Mol Imaging Biol (2016)

A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells

by Hight, Matthew R., Cheung, Yiu-Yin, Nickels, Michael L., Dawson, Eric S., Zhao, Ping, Saleh, Samir, Buck, Jason R., Tang, Dewei, Washington, M. Kay, Coffey, Robert J., Manning, H. Charles
Published 2014

Utility of [(18)F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population

by Kavanaugh, Gina, Williams, Jason, Morris, Andrew Scott, Nickels, Michael L., Walker, Ronald, Koglin, Norman, Stephens, Andrew W., Washington, M. Kay, Geevarghese, Sunil K., Liu, Qi, Ayers, Dan, Shyr, Yu, Manning, H. Charles
Published in Mol Imaging Biol (2016)

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

by Luo, Na, Nixon, Mellissa J., Gonzalez-Ericsson, Paula I., Sanchez, Violeta, Opalenik, Susan R., Li, Huili, Zahnow, Cynthia A., Nickels, Michael L., Liu, Fei, Tantawy, Mohammed N., Sanders, Melinda E., Manning, H. Charles, Balko, Justin M.
Published in Nat Commun (2018)

Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults

by Smith, Christopher T., San Juan, M. Danica, Dang, Linh C., Katz, Daniel T., Perkins, Scott F., Burgess, Leah L., Cowan, Ronald L., Manning, H. Charles, Nickels, Michael L., Claassen, Daniel O., Samanez-Larkin, Gregory R., Zald, David H.
Published in Transl Psychiatry (2018)

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer

by Uddin, Md. Jashim, Wilson, Andrew J., Crews, Brenda C., Malerba, Paola, Uddin, Md. Imam, Kingsley, Philip J., Ghebreselasie, Kebreab, Daniel, Cristina K., Nickels, Michael L., Tantawy, Mohammed N., Jashim, Elma, Manning, H. Charles, Khabele, Dineo, Marnett, Lawrence J.
Published in ACS Omega (2019)

Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models

by Schulte, Michael L., Fu, Allie, Zhao, Ping, Li, Jun, Geng, Ling, Smith, Shannon T., Kondo, Jumpei, Coffey, Robert J., Johnson, Marc O., Rathmell, Jeffrey C., Sharick, Joe T., Skala, Melissa C., Smith, Jarrod A., Berlin, Jordan, Washington, M. Kay, Nickels, Michael L., Manning, H. Charles
Published in Nat Med (2018)