Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons

por Bradford, Aaron B, McNutt, Patrick M
Publicado en World J Stem Cells (2015)

The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries

por McNutt, Patrick M., Mohan, Rajiv R.
Publicado en Transl Vis Sci Technol (2020)

Abstracts of Presentations from the 2020 Trans-Agency Scientific Meeting on Developing Medical Countermeasures to Treat the Acute and Chronic Effects of Ocular Chemical Toxicity, 2...

por Yeung, David T., Araj, Houmam, McNutt, Patrick M.
Publicado en Toxicol Lett (2020)

Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals

por Winner, Brittany M., Bodt, Skylar M. L., McNutt, Patrick M.
Publicado en Int J Mol Sci (2020)

Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs

por Hubbard, Kyle S, Gut, Ian M, Lyman, Megan E, McNutt, Patrick M
Publicado 2013

Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing

por Beske, Phillip H., Scheeler, Stephen M., Adler, Michael, McNutt, Patrick M.
Publicado en Front Cell Neurosci (2015)

Compatibility of SYTO 13 and Hoechst 33342 for longitudinal imaging of neuron viability and cell death

por Hubbard, Kyle S, Gut, Ian M, Scheeler, Stephen M, Lyman, Megan E, McNutt, Patrick M
Publicado 2012

Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A

por Beske, Phillip H., Hoffman, Katie M., Machamer, James B., Eisen, Margaret R., McNutt, Patrick M.
Publicado en Sci Rep (2017)

High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research

por Hubbard, Kyle S, Gut, Ian M, Lyman, Megan E, Tuznik, Kaylie M, Mesngon, Mariano T, McNutt, Patrick M
Publicado 2012

Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid

por Andres, Devon, Keyser, Brian M, Petrali, John, Benton, Betty, Hubbard, Kyle S, McNutt, Patrick M, Ray, Radharaman
Publicado 2013

Novel Application of Stem Cell-Derived Neurons to Evaluate the Time- and Dose-Dependent Progression of Excitotoxic Injury

por Gut, Ian M., Beske, Phillip H., Hubbard, Kyle S., Lyman, Megan E., Hamilton, Tracey A., McNutt, Patrick M.
Publicado 2013

Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor

por McNutt, Patrick M., Tuznik, Kaylie M., Glotfelty, Elliot J., Nelson, Marian R., Lyman, Megan E., Hamilton, Tracey A.
Publicado en Ann N Y Acad Sci (2016)

Retrograde activation of CB1R by muscarinic receptors protects against central organophosphorus toxicity

por Hoffman, Katie M., Eisen, Margaret R., Chandler, Jessica K., Nelson, Marian R., Johnson, Erik A., McNutt, Patrick M.
Publicado en Neuropharmacology (2019)

Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons

por Beske, Phillip H., Bradford, Aaron B., Grynovicki, Justin O., Glotfelty, Elliot J., Hoffman, Katie M., Hubbard, Kyle S., Tuznik, Kaylie M., McNutt, Patrick M.
Publicado en Toxicol Sci (2016)

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins

por Lam, Kwok-ho, Tremblay, Jacqueline M., Vazquez-Cintron, Edwin, Perry, Kay, Ondeck, Celinia, Webb, Robert P., McNutt, Patrick M., Shoemaker, Charles B., Jin, Rongsheng
Publicado en Cell Rep (2020)

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

por Tremblay, Jacqueline M., Vazquez-Cintron, Edwin, Lam, Kwok-Ho, Mukherjee, Jean, Bedenice, Daniela, Ondeck, Celinia A., Conroy, Matthieu T., Bodt, Skylar M. L., Winner, Brittany M., Webb, Robert P., Ichtchenko, Konstantin, Jin, Rongsheng, McNutt, Patrick M., Shoemaker, Charles B.
Publicado en Toxins (Basel) (2020)

Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery

por Vazquez-Cintron, Edwin J., Beske, Phillip H., Tenezaca, Luis, Tran, Bao Q., Oyler, Jonathan M., Glotfelty, Elliot J., Angeles, Christopher A., Syngkon, Aurelia, Mukherjee, Jean, Kalb, Suzanne R., Band, Philip A., McNutt, Patrick M., Shoemaker, Charles B., Ichtchenko, Konstantin
Publicado en Sci Rep (2017)

Neuronal delivery of antibodies has therapeutic effects in animal models of botulism

por McNutt, Patrick M., Vazquez-Cintron, Edwin J., Tenezaca, Luis, Ondeck, Celinia A., Kelly, Kyle E., Mangkhalakhili, Mark, Machamer, James B., Angeles, Christopher A., Glotfelty, Elliot J., Cika, Jaclyn, Benjumea, Cesar H., Whitfield, Justin T., Band, Philip A., Shoemaker, Charles B., Ichtchenko, Konstantin
Publicado en Sci Transl Med (2021)

Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice

por McCarren, Hilary S., Eisen, Margaret R., Nguyen, Dominique L., Dubée, Parker B., Ardinger, Cherish E., Dunn, Emily N., Haines, Kari M., Santoro, Antonia N., Bodner, Paige M., Ondeck, Celinia A., Honnold, Cary L., McDonough, John H., Beske, Phillip H., McNutt, Patrick M.
Publicado en Epilepsy Res (2020)