Novel Application of Stem Cell-Derived Neurons to Evaluate the Time- and Dose-Dependent Progression of Excitotoxic Injury

Glutamate receptor (GluR)-mediated neurotoxicity is implicated in a variety of disorders ranging from ischemia to neural degeneration. Under conditions of elevated glutamate, the excessive activation of GluRs causes internalization of pathologic levels of Ca(2+), culminating in bioenergetic failure,...

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Bibliografiske detaljer
Main Authors: Gut, Ian M., Beske, Phillip H., Hubbard, Kyle S., Lyman, Megan E., Hamilton, Tracey A., McNutt, Patrick M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653859/
https://ncbi.nlm.nih.gov/pubmed/23691214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064423
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