Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery

Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vazquez-Cintron, Edwin J., Beske, Phillip H., Tenezaca, Luis, Tran, Bao Q., Oyler, Jonathan M., Glotfelty, Elliot J., Angeles, Christopher A., Syngkon, Aurelia, Mukherjee, Jean, Kalb, Suzanne R., Band, Philip A., McNutt, Patrick M., Shoemaker, Charles B., Ichtchenko, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318933/
https://ncbi.nlm.nih.gov/pubmed/28220863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42923
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