Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression

Por Valenciano, Ana L, Ramsey, Aaron C, Mackey, Zachary B
Publicado no Cell Cycle (2015)

Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties

Por Valenciano, Ana L., Knudsen, Giselle M., Mackey, Zachary B.
Publicado no Cell Cycle (2016)

Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair

Por Leppard, John B., Dong, Zhiwan, Mackey, Zachary B., Tomkinson, Alan E.
Publicado em 2003

High Throughput Analysis of an RNAi Library Identifies Novel Kinase targets in Trypanosoma brucei

Por Mackey, Zachary B., Koupparis, Kyriacos, Nishino, Mari, McKerrow, James H.
Publicado em 2011

Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei

Por Kerr, Iain D., Wu, Peng, Marion-Tsukamaki, Rachael, Mackey, Zachary B., Brinen, Linda S.
Publicado em 2010

RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model

Por Abdulla, Maha-Hamadien, O'Brien, Theresa, Mackey, Zachary B., Sajid, Mohamed, Grab, Dennis J., McKerrow, James H.
Publicado em 2008

Early Invasion of Brain Parenchyma by African Trypanosomes

Por Frevert, Ute, Movila, Alexandru, Nikolskaia, Olga V., Raper, Jayne, Mackey, Zachary B., Abdulla, Maha, McKerrow, James, Grab, Dennis J.
Publicado em 2012

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

Por Chen, Chiung-Kuang, Doyle, Patricia S., Yermalitskaya, Liudmila V., Mackey, Zachary B., Ang, Kenny K. H., McKerrow, James H., Podust, Larissa M.
Publicado em 2009

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

Por O'Brien, Theresa C., Mackey, Zachary B., Fetter, Richard D., Choe, Youngchool, O'Donoghue, Anthony J., Zhou, Min, Craik, Charles S., Caffrey, Conor R., McKerrow, James H.
Publicado em 2008

Examination of the Mode of Action of the Almiramide Family of Natural Products Against the Kinetoplastid Parasite Trypanosoma brucei

Por Sanchez, Laura M., Knudsen, Giselle M., Hartmann, Claudia, De Muylder, Geraldine, Mascuch, Samantha M., Mackey, Zachary B., Gerwick, Lena, Clayton, Christine, McKerrow, James H., Linington, Roger G.
Publicado em 2013

Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii

Por Liu, Chao-Lin, Shen, Chia-Rui, Hsu, Fong-Fu, Chen, Jeen-Kuan, Wu, Pei-Tzu, Guo, Shang-Hsin, Lee, Wen-Chien, Yu, Feng-Wei, Mackey, Zachary B., Turk, John, Gross, Michael L.
Publicado em 2009

A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection

Por Ndao, Momar, Nath-Chowdhury, Milli, Sajid, Mohammed, Marcus, Victoria, Mashiyama, Susan T., Sakanari, Judy, Chow, Eric, Mackey, Zachary, Land, Kirkwood M., Jacobson, Matthew P., Kalyanaraman, Chakrapani, McKerrow, James H., Arrowood, Michael J., Caffrey, Conor R.
Publicado em 2013

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

Por Ang, Kenny K. H., Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B., Skrzypczynska, Katarzyna M., Debnath, Anjan, Engel, Juan C., Rosenthal, Philip J., McKerrow, James H., Arkin, Michelle R., Renslo, Adam R.
Publicado em 2011