Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping sickness, Chagas' disease, and malaria. The homology of parasite cysteine proteases to the human cathepsins suggests that inhibitors origina...

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Detaylı Bibliyografya
Asıl Yazarlar: Ang, Kenny K. H., Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B., Skrzypczynska, Katarzyna M., Debnath, Anjan, Engel, Juan C., Rosenthal, Philip J., McKerrow, James H., Arkin, Michelle R., Renslo, Adam R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086806/
https://ncbi.nlm.nih.gov/pubmed/21572521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001023
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