Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

Cysteine proteases of the papain superfamily are implicated in a number of cellular processes and are important virulence factors in the pathogenesis of parasitic disease. These enzymes have therefore emerged as promising targets for antiparasitic drugs. We report the crystal structures of three maj...

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Detalhes bibliográficos
Main Authors: Kerr, Iain D., Lee, Ji H., Farady, Christopher J., Marion, Rachael, Rickert, Mathias, Sajid, Mohammed, Pandey, Kailash C., Caffrey, Conor R., Legac, Jennifer, Hansell, Elizabeth, McKerrow, James H., Craik, Charles S., Rosenthal, Philip J., Brinen, Linda S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757971/
https://ncbi.nlm.nih.gov/pubmed/19620707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014340
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