A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

Cysteine proteases of the Clan CA (papain) family are the predominant protease group in primitive invertebrates. Cysteine protease inhibitors arrest infection by the protozoan parasite, Trypanosoma brucei. RNA interference studies implicated a cathepsin B-like protease, tbcatB, as a key inhibitor ta...

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Detalhes bibliográficos
Main Authors: O'Brien, Theresa C., Mackey, Zachary B., Fetter, Richard D., Choe, Youngchool, O'Donoghue, Anthony J., Zhou, Min, Craik, Charles S., Caffrey, Conor R., McKerrow, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570886/
https://ncbi.nlm.nih.gov/pubmed/18701454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805824200
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