Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

Por Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David A., Fairlie, David P., Craik, David J.
Publicado no Proc Natl Acad Sci U S A (2014)

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

Por Seow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y., Fairlie, David P.
Publicado no Sci Rep (2016)

PAR2 Modulators Derived from GB88

Por Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C., Fairlie, David P.
Publicado no ACS Med Chem Lett (2016)

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

Por Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J., Fairlie, David P.
Publicado em 2014