ロード中...
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
Drug discovery and translation are normally based on optimizing efficacy by increasing receptor affinity, functional potency, drug-likeness (rule-of-five compliance) and oral bioavailability. Here we demonstrate that residence time of a compound on its receptor has an overriding influence on efficac...
保存先:
| 出版年: | Sci Rep |
|---|---|
| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4837355/ https://ncbi.nlm.nih.gov/pubmed/27094554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24575 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|