Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects

por Dupont, J, Le Roith, D
Publicado em 2001

MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity

por Vaitheesvaran, B., LeRoith, D., Kurland, I. J.
Publicado no Diabetologia (2010)

Insulin-like growth factor I is required for vessel remodeling in the adult brain

por Lopez-Lopez, C., LeRoith, D., Torres-Aleman, I.
Publicado em 2004

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

por Werner, H, Karnieli, E, Rauscher, F J, LeRoith, D
Publicado em 1996

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

por Lowe, W L, Roberts, C T, Lasky, S R, LeRoith, D
Publicado em 1987

Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes.

por Le Roith, D, Shiloach, J, Roth, J, Lesniak, M A
Publicado em 1980

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

por Neuenschwander, S, Schwartz, A, Wood, T L, Roberts, C T, Hennighausen, L, LeRoith, D
Publicado em 1996

Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.

por Lowe, W L, Adamo, M, Werner, H, Roberts, C T, LeRoith, D
Publicado em 1989

Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

por Novosyadlyy, R, Vijayakumar, A, Lann, D, Fierz, Y, Kurshan, N, LeRoith, D
Publicado em 2009

Developmental regulation of the rat insulin-like growth factor I receptor gene.

por Werner, H, Woloschak, M, Adamo, M, Shen-Orr, Z, Roberts, C T, LeRoith, D
Publicado em 1989

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.

por Porcu, P, Ferber, A, Pietrzkowski, Z, Roberts, C T, Adamo, M, LeRoith, D, Baserga, R
Publicado em 1992

Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats.

por Nadiv, O, Shinitzky, M, Manu, H, Hecht, D, Roberts, C T, LeRoith, D, Zick, Y
Publicado em 1994

Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus

por Kawashima, Y., Chen, J., Sun, H., Lann, D., Hajjar, R. J., Yakar, S., LeRoith, D.
Publicado no Diabetologia (2009)

Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression.

por Werner, H, Shen-Orr, Z, Rauscher, F J, Morris, J F, Roberts, C T, LeRoith, D
Publicado em 1995

Corticotropin and β-endorphin-like materials are native to unicellular organisms

por LeRoith, D., Liotta, A. S., Roth, J., Shiloach, J., Lewis, M. E., Pert, C. B., Krieger, D. T.
Publicado em 1982

Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.

por Wang, J, Niu, W, Nikiforov, Y, Naito, S, Chernausek, S, Witte, D, LeRoith, D, Strauch, A, Fagin, J A
Publicado em 1997

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene p...

por Werner, H, Re, G G, Drummond, I A, Sukhatme, V P, Rauscher, F J, Sens, D A, Garvin, A J, LeRoith, D, Roberts, C T
Publicado em 1993