Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

Wilms tumor is a pediatric neoplasm that arises from the metanephric blastema. The expression of the gene encoding insulin-like growth factor II (IGF-II) is often elevated in these tumors. Since many of the actions of IGF-II are mediated through activation of the IGF-I receptor (IGF-IR), we have mea...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Werner, H, Re, G G, Drummond, I A, Sukhatme, V P, Rauscher, F J, Sens, D A, Garvin, A J, LeRoith, D, Roberts, C T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46816/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8390684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.12.5828
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