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A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1.

The putative Wilms tumor suppressor gene, wt1, encodes a zinc-finger protein that binds to the DNA sequence 5'-GCGGGGGCG-3'. We previously reported that WT1 has separable domains that function either to activate or suppress transcription. We now have identified a second WT1 binding sequence (5'-TCCT...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Wang, Z Y, Qiu, Q Q, Enger, K T, Deuel, T F
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47467/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415628/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.19.8896
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