Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan: EVIDENCE FOR THE INVOLVEMENT OF HtrA1 IN AGGRECAN PROTEOLYSIS IN VIVO

Por Chamberland, Angela, Wang, Eunice, Jones, Aled R., Collins-Racie, Lisa A., LaVallie, Edward R., Huang, Ying, Liu, Lin, Morris, Elisabeth A., Flannery, Carl R., Yang, Zhiyong
Publicado em 2009

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

Por Tu, Chao, Terraube, Virginie, Tam, Amy Sze Pui, Stochaj, Wayne, Fennell, Brian J., Lin, Laura, Stahl, Mark, LaVallie, Edward R., Somers, Will, Finlay, William J. J., Mosyak, Lydia, Bard, Joel, Cunningham, Orla
Publicado no J Biol Chem (2016)

Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

Por Bechard Theresa, Ryan Mark, LaVallie Edward R, Young Deborah, Corcoran Christopher, Immermann Frederick W, Ramsey Renee C, Hill Andrew A, Guo Yongjing, Pfeifer Richard, Warner Garvin, Bologna Marcia, Bloom Laird, O'Toole Margot
Publicado em 2010-05-01

Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody

Por Guo, Yongjing, Hill, Andrew A, Ramsey, Renee C, Immermann, Frederick W, Corcoran, Christopher, Young, Deborah, LaVallie, Edward R, Ryan, Mark, Bechard, Theresa, Pfeifer, Richard, Warner, Garvin, Bologna, Marcia, Bloom, Laird, O'Toole, Margot
Publicado em 2010

Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

Por Arai, Maya, Jain, Sadhana, Weaver, Amy A, Hill, Andrew A, Guo, Yongjing, Bree, Andrea G, Smith, Michael F, Allen, Scott W, LaVallie, Edward R, Young, Deborah, Bloom, Laird, Adkins, Karissa, O'Toole, Margot
Publicado em 2010

LXR modulation blocks prostaglandin E(2) production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Por Li, Ning, Rivéra-Bermúdez, Moisés A., Zhang, Mei, Tejada, Julio, Glasson, Sonya S., Collins-Racie, Lisa A., LaVallie, Edward R., Wang, Yihe, Chang, Ken C. N., Nagpal, Sunil, Morris, Elisabeth A., Flannery, Carl R., Yang, Zhiyong
Publicado em 2010

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Por DiBlasio-Smith, Elizabeth A, Arai, Maya, Quinet, Elaine M, Evans, Mark J, Kornaga, Tad, Basso, Michael D, Chen, Liang, Feingold, Irene, Halpern, Anita R, Liu, Qiang-Yuan, Nambi, Ponnal, Savio, Dawn, Wang, Shuguang, Mounts, William M, Isler, Jennifer A, Slager, Anna M, Burczynski, Michael E, Dorner, Andrew J, LaVallie, Edward R
Publicado em 2008

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

Por Quinet, Elaine M., Basso, Michael D., Halpern, Anita R., Yates, David W., Steffan, Robert J., Clerin, Valerie, Resmini, Christine, Keith, James C., Berrodin, Thomas J., Feingold, Irene, Zhong, Wenyan, Hartman, Helen B., Evans, Mark J., Gardell, Stephen J., DiBlasio-Smith, Elizabeth, Mounts, William M., LaVallie, Edward R., Wrobel, Jay, Nambi, Ponnal, Vlasuk, George P.
Publicado em 2009

An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

Por Shih, Heather H., Tu, Chao, Cao, Wei, Klein, Anne, Ramsey, Renee, Fennell, Brian J., Lambert, Matthew, Ní Shúilleabháin, Deirdre, Autin, Bénédicte, Kouranova, Eugenia, Laxmanan, Sri, Braithwaite, Steven, Wu, Leeying, Ait-Zahra, Mostafa, Milici, Anthony J., Dumin, Jo Ann, LaVallie, Edward R., Arai, Maya, Corcoran, Christopher, Paulsen, Janet E., Gill, Davinder, Cunningham, Orla, Bard, Joel, Mosyak, Lydia, Finlay, William J. J.
Publicado em 2012