An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

Highly specific antibodies to phosphoepitopes are valuable tools to study phosphorylation in disease states, but their discovery is largely empirical, and the molecular mechanisms mediating phosphospecific binding are poorly understood. Here, we report the generation and characterization of extremel...

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Detalhes bibliográficos
Main Authors: Shih, Heather H., Tu, Chao, Cao, Wei, Klein, Anne, Ramsey, Renee, Fennell, Brian J., Lambert, Matthew, Ní Shúilleabháin, Deirdre, Autin, Bénédicte, Kouranova, Eugenia, Laxmanan, Sri, Braithwaite, Steven, Wu, Leeying, Ait-Zahra, Mostafa, Milici, Anthony J., Dumin, Jo Ann, LaVallie, Edward R., Arai, Maya, Corcoran, Christopher, Paulsen, Janet E., Gill, Davinder, Cunningham, Orla, Bard, Joel, Mosyak, Lydia, Finlay, William J. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531756/
https://ncbi.nlm.nih.gov/pubmed/23148212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415935
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