Toxin Binding of Tolevamer, a Polyanionic Drug that Protects against Antibiotic-Associated Diarrhea

Por Braunlin, William, Xu, Qiuwei, Hook, Patrick, Fitzpatrick, Richard, Klinger, Jeffrey D., Burrier, Robert, Kurtz, Caroline B.
Publicado em 2004

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Por Hannig, Gerhard, Tchernychev, Boris, Kurtz, Caroline B., Bryant, Alexander P., Currie, Mark G., Silos-Santiago, Inmaculada
Publicado em 2014

Assessment of treatment response in chronic constipation clinical trials

Por Ervin, Claire M, Fehnel, Sheri E, Baird, Mollie J, Carson, Robyn T, Johnston, Jeffrey M, Shiff, Steven J, Kurtz, Caroline B, Mangel, Allen W
Publicado em 2014

Psychometric validation of patient-reported outcome measures assessing chronic constipation

Por Nelson, Lauren M, Williams, Valerie SL, Fehnel, Sheri E, Carson, Robyn T, MacDougall, James, Baird, Mollie J, Tourkodimitris, Stavros, Kurtz, Caroline B, Johnston, Jeffrey M
Publicado em 2014

Comparison of adequate relief with symptom, global, and responder endpoints in linaclotide phase 3 trials in IBS-C

Por Camilleri, Michael, Lembo, Anthony J, Lavins, Bernard J, MacDougall, James E, Carson, Robyn T, Williams, Valerie SL, Nelson, Lauren M, Shiff, Steven J, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M
Publicado no United European Gastroenterol J (2015)

Guanylate cyclase 2C agonism corrects CFTR mutants

Por Arora, Kavisha, Huang, Yunjie, Mun, Kyushik, Yarlagadda, Sunitha, Sundaram, Nambirajan, Kessler, Marco M., Hannig, Gerhard, Kurtz, Caroline B., Silos-Santiago, Inmaculada, Helmrath, Michael, Palermo, Joseph J., Clancy, John P., Steinbrecher, Kris A., Naren, Anjaparavanda P.
Publicado no JCI Insight (2017)

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

Por Lacy, Brian E., Schey, Ron, Shiff, Steven J., Lavins, Bernard J., Fox, Susan M., Jia, Xinwei D., Blakesley, Rick E., Hao, Xinming, Cronin, Jacquelyn A., Currie, Mark G., Kurtz, Caroline B., Johnston, Jeffrey M., Lembo, Anthony J.
Publicado no PLoS One (2015)

GT160-246, a Toxin Binding Polymer for Treatment of Clostridium difficile Colitis

Por Kurtz, Caroline B., Cannon, E. Pat, Brezzani, Alex, Pitruzzello, Mary, Dinardo, Carol, Rinard, Emilie, Acheson, David W. K., Fitzpatrick, Richard, Kelly, Pamela, Shackett, Keith, Papoulis, Andrew T., Goddard, Philip J., Barker, Robert H., Palace, Gerard P., Klinger, Jeffrey D.
Publicado em 2001

Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

Por Schoenfeld, Philip, Lacy, Brian E, Chey, William D, Lembo, Anthony J, Kurtz, Caroline B, Reasner, David S, Bochenek, Wieslaw, Tripp, Kenneth, Currie, Mark G, Fox, Susan M, Blakesley, Rick E, O’Dea, Christopher R, Omniewski, Nicholas D, Hall, Michael L
Publicado no Am J Gastroenterol (2018)

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

Por Rao, Satish, Lembo, Anthony J, Shiff, Steven J, Lavins, Bernard J, Currie, Mark G, Jia, Xinwei D, Shi, Kelvin, MacDougall, James E, Shao, James Z, Eng, Paul, Fox, Susan M, Schneier, Harvey A, Kurtz, Caroline B, Johnston, Jeffrey M
Publicado em 2012