Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

OBJECTIVES: Linaclotide is a guanylate cyclase-C agonist approved in the United States, Canada, and Mexico at a once-daily 145-μg dose for the treatment of chronic idiopathic constipation (CIC); a once-daily 72-μg dose for CIC recently received FDA approval. The trial objective was to evaluate the e...

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Detalhes bibliográficos
Publicado no:Am J Gastroenterol
Main Authors: Schoenfeld, Philip, Lacy, Brian E, Chey, William D, Lembo, Anthony J, Kurtz, Caroline B, Reasner, David S, Bochenek, Wieslaw, Tripp, Kenneth, Currie, Mark G, Fox, Susan M, Blakesley, Rick E, O’Dea, Christopher R, Omniewski, Nicholas D, Hall, Michael L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Functional GI Disorders
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770595/
https://ncbi.nlm.nih.gov/pubmed/29091082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajg.2017.230
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