Inventing Liraglutide, a Glucagon-Like Peptide-1 Analogue, for the Treatment of Diabetes and Obesity

par Knudsen, Lotte Bjerre
Publié dans ACS Pharmacol Transl Sci (2019)

The Discovery and Development of Liraglutide and Semaglutide

par Knudsen, Lotte Bjerre, Lau, Jesper
Publié dans Front Endocrinol (Lausanne) (2019)

Comment on Andersen et al, Pancreatitis–Diabetes–Pancreatic Cancer: Summary of an NIDDK-NCI Workshop

par Moses, Alan Charles, Knudsen, Lotte Bjerre, Svendsen, Claus Bo
Publié 2014

Long‐acting glucagon‐like peptide‐1 receptor agonists have direct access to and effects on pro‐opiomelanocortin/cocaine‐ and amphetamine‐stimulated transcript neurons in the mouse...

par Knudsen, Lotte Bjerre, Secher, Anna, Hecksher‐Sørensen, Jacob, Pyke, Charles
Publié dans J Diabetes Investig (2016)

Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas

par Tornehave, Ditte, Kristensen, Peter, Rømer, John, Knudsen, Lotte Bjerre, Heller, R. Scott
Publié 2008

Activation of the renal GLP‐1R leads to expression of Ren1 in the renal vascular tree

par Bjørnholm, Katrine Dahl, Ougaard, Maria Elm, Skovsted, Gry Freja, Knudsen, Lotte Bjerre, Pyke, Charles
Publié dans Endocrinol Diabetes Metab (2021)

Robust use of phenotypic heterogeneity at drug target genes for mechanistic insights: application of cis-multivariable Mendelian randomization to GLP1R gene region

par Patel, Ashish, Gill, Dipender, Shungin, Dmitry, Mantzoros, Christos S., Knudsen, Lotte Bjerre, Bowden, Jack, Burgess, Stephen
Publié dans Genet Epidemiol (2024)

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

par Underwood, Christina Rye, Garibay, Patrick, Knudsen, Lotte Bjerre, Hastrup, Sven, Peters, Günther H., Rudolph, Rainer, Reedtz-Runge, Steffen
Publié 2010

The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE(−/−) and LDLr(−/−) Mice by a Mechanism That Includes Inflammatory Pathways

par Rakipovski, Günaj, Rolin, Bidda, Nøhr, Jane, Klewe, Ib, Frederiksen, Klaus S., Augustin, Robert, Hecksher-Sørensen, Jacob, Ingvorsen, Camilla, Polex-Wolf, Joseph, Knudsen, Lotte Bjerre
Publié dans JACC Basic Transl Sci (2018)

Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain

par Farkas, Erzsébet, Szilvásy-Szabó, Anett, Ruska, Yvette, Sinkó, Richárd, Rasch, Morten Grønbech, Egebjerg, Thomas, Pyke, Charles, Gereben, Balázs, Knudsen, Lotte Bjerre, Fekete, Csaba
Publié dans Brain Struct Funct (2020)

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer’s Disease

par Hansen, Henrik H., Fabricius, Katrine, Barkholt, Pernille, Niehoff, Michael L., Morley, John E., Jelsing, Jacob, Pyke, Charles, Knudsen, Lotte Bjerre, Farr, Susan A., Vrang, Niels
Publié dans J Alzheimers Dis (2015)

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer...

par Hansen, Henrik H., Fabricius, Katrine, Barkholt, Pernille, Kongsbak-Wismann, Pernille, Schlumberger, Chantal, Jelsing, Jacob, Terwel, Dick, Termont, Annelies, Pyke, Charles, Knudsen, Lotte Bjerre, Vrang, Niels
Publié dans PLoS One (2016)

GLP-1 derivative liraglutide in rats with β-cell deficiencies: influence of metabolic state on β-cell mass dynamics

par Sturis, Jeppe, Gotfredsen, Carsten F, Rømer, John, Rolin, Bidda, Ribel, Ulla, Brand, Christian L, Wilken, Michael, Wassermann, Karsten, Deacon, Carolyn F, Carr, Richard D, Knudsen, Lotte Bjerre
Publié 2003

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

par Dowsett, Georgina K.C., Lam, Brian Y.H., Tadross, John A., Cimino, Irene, Rimmington, Debra, Coll, Anthony P., Polex-Wolf, Joseph, Knudsen, Lotte Bjerre, Pyke, Charles, Yeo, Giles S.H.
Publié dans Mol Metab (2021)

Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment

par Salinas, Casper Bo Gravesen, Lu, Tess Tsai-Hsiu, Gabery, Sanaz, Marstal, Kasper, Alanentalo, Tomas, Mercer, Aaron Jeffrey, Cornea, Anda, Conradsen, Knut, Hecksher-Sørensen, Jacob, Dahl, Anders Bjorholm, Knudsen, Lotte Bjerre, Secher, Anna
Publié dans Sci Rep (2018)

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

par Roostalu, Urmas, Salinas, Casper B. G., Thorbek, Ditte D., Skytte, Jacob L., Fabricius, Katrine, Barkholt, Pernille, John, Linu M., Jurtz, Vanessa Isabell, Knudsen, Lotte Bjerre, Jelsing, Jacob, Vrang, Niels, Hansen, Henrik H., Hecksher-Sørensen, Jacob
Publié dans Dis Model Mech (2019)

Small-molecule agonists for the glucagon-like peptide 1 receptor

par Knudsen, Lotte Bjerre, Kiel, Dan, Teng, Min, Behrens, Carsten, Bhumralkar, Dilip, Kodra, János T., Holst, Jens J., Jeppesen, Claus B., Johnson, Michael D., de Jong, Johannes Cornelis, Jorgensen, Anker Steen, Kercher, Tim, Kostrowicki, Jarek, Madsen, Peter, Olesen, Preben H., Petersen, Jacob S., Poulsen, Fritz, Sidelmann, Ulla G., Sturis, Jeppe, Truesdale, Larry, May, John, Lau, Jesper
Publié 2007

Semaglutide lowers body weight in rodents via distributed neural pathways

par Gabery, Sanaz, Salinas, Casper G., Paulsen, Sarah J., Ahnfelt-Rønne, Jonas, Alanentalo, Tomas, Baquero, Arian F., Buckley, Stephen T., Farkas, Erzsébet, Fekete, Csaba, Frederiksen, Klaus S., Hogendorf, Wouter Frederik Johan, Helms, Hans Christian C., Jeppesen, Jacob F., John, Linu M., Pyke, Charles, Nøhr, Jane, Lu, Tess T., Polex-Wolf, Joseph, Prevot, Vincent, Raun, Kirsten, Simonsen, Lotte, Sun, Gao, Szilvásy-Szabó, Anett, Willenbrock, Hanni, Secher, Anna, Knudsen, Lotte Bjerre
Publié dans JCI Insight (2020)