Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

One of the major histopathological hallmarks of Alzheimer’s disease (AD) is cerebral deposits of extracellular β-amyloid peptides. Preclinical studies have pointed to glucagon-like peptide 1 (GLP-1) receptors as a potential novel target in the treatment of AD. GLP-1 receptor agonists, including exen...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hansen, Henrik H., Fabricius, Katrine, Barkholt, Pernille, Kongsbak-Wismann, Pernille, Schlumberger, Chantal, Jelsing, Jacob, Terwel, Dick, Termont, Annelies, Pyke, Charles, Knudsen, Lotte Bjerre, Vrang, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946784/
https://ncbi.nlm.nih.gov/pubmed/27421117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158205
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