Stratification and prediction of drug synergy based on target functional similarity

door Yang, Mi, Jaaks, Patricia, Dry, Jonathan, Garnett, Mathew, Menden, Michael P., Saez-Rodriguez, Julio
Gepubliceerd in NPJ Syst Biol Appl (2020)

The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion

door Jaaks, Patricia, D’Alessandro, Valentina, Grob, Nicole, Büel, Sina, Hajdin, Katarina, Schäfer, Beat W., Bernasconi, Michele
Gepubliceerd in PLoS One (2016)

Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

door Eduati, Federica, Jaaks, Patricia, Wappler, Jessica, Cramer, Thorsten, Merten, Christoph A, Garnett, Mathew J, Saez‐Rodriguez, Julio
Gepubliceerd in Mol Syst Biol (2020)

Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

door Eduati, Federica, Jaaks, Patricia, Wappler, Jessica, Cramer, Thorsten, Merten, Christoph A, Garnett, Mathew J, Saez‐Rodriguez, Julio
Gepubliceerd in Mol Syst Biol (2020)

The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells

door Jaaks, Patricia, Meier, Gianmarco, Alijaj, Nagjie, Brack, Eva, Bode, Peter, Koscielniak, Ewa, Wachtel, Marco, Schäfer, Beat W., Bernasconi, Michele
Gepubliceerd in Oncotarget (2016)

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth

door Gierisch, Maria E., Pedot, Gloria, Walser, Franziska, Lopez-Garcia, Laura A., Jaaks, Patricia, Niggli, Felix K., Schäfer, Beat W.
Gepubliceerd in Sci Rep (2019)

Transcription factor activities enhance markers of drug sensitivity in cancer

door Garcia-Alonso, Luz, Iorio, Francesco, Matchan, Angela, Fonseca, Nuno, Jaaks, Patricia, Peat, Gareth, Pignatelli, Miguel, Falcone, Fiammetta, Benes, Cyril H., Dunham, Ian, Bignell, Graham, McDade, Simon S., Garnett, Mathew J., Saez-Rodriguez, Julio
Gepubliceerd in Cancer Res (2018)

Integrated cross-study datasets of genetic dependencies in cancer

door Pacini, Clare, Dempster, Joshua M., Boyle, Isabella, Gonçalves, Emanuel, Najgebauer, Hanna, Karakoc, Emre, van der Meer, Dieudonne, Barthorpe, Andrew, Lightfoot, Howard, Jaaks, Patricia, McFarland, James M., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco
Gepubliceerd in Nat Commun (2021)

SLFN11 informs on standard of care and novel treatments in a wide range of cancer models

door Winkler, Claudia, Armenia, Joshua, Jones, Gemma N., Tobalina, Luis, Sale, Matthew J., Petreus, Tudor, Baird, Tarrion, Serra, Violeta, Wang, Anderson T., Lau, Alan, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Pierce, Andrew J., O’Connor, Mark J., Leo, Elisabetta
Gepubliceerd in Br J Cancer (2020)

Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens

door Gonçalves, Emanuel, Segura‐Cabrera, Aldo, Pacini, Clare, Picco, Gabriele, Behan, Fiona M, Jaaks, Patricia, Coker, Elizabeth A, van der Meer, Donny, Barthorpe, Andrew, Lightfoot, Howard, Mironenko, Tatiana, Beck, Alexandra, Richardson, Laura, Yang, Wanjuan, Lleshi, Ermira, Hall, James, Tolley, Charlotte, Hall, Caitlin, Mali, Iman, Thomas, Frances, Morris, James, Leach, Andrew R, Lynch, James T, Sidders, Ben, Crafter, Claire, Iorio, Francesco, Fawell, Stephen, Garnett, Mathew J
Gepubliceerd in Mol Syst Biol (2020)