Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract.

Por Cantin, A M, Fells, G A, Hubbard, R C, Crystal, R G
Publicado em 1990

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.

Por Hubbard, R C, Fells, G, Gadek, J, Pacholok, S, Humes, J, Crystal, R G
Publicado em 1991

Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.

Por Ogushi, F, Hubbard, R C, Vogelmeier, C, Fells, G A, Crystal, R G
Publicado em 1991

Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele.

Por Curiel, D T, Vogelmeier, C, Hubbard, R C, Stier, L E, Crystal, R G
Publicado em 1990

Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.

Por Ogushi, F, Fells, G A, Hubbard, R C, Straus, S D, Crystal, R G
Publicado em 1987

Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.

Por Cantin, A M, North, S L, Fells, G A, Hubbard, R C, Crystal, R G
Publicado em 1987

Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin defic...

Por Hubbard, R C, McElvaney, N G, Sellers, S E, Healy, J T, Czerski, D B, Crystal, R G
Publicado em 1989

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neut...

Por Hubbard, R C, Ogushi, F, Fells, G A, Cantin, A M, Jallat, S, Courtney, M, Crystal, R G
Publicado em 1987

Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.

Por Hubbard, R C, Casolaro, M A, Mitchell, M, Sellers, S E, Arabia, F, Matthay, M A, Crystal, R G
Publicado em 1989

Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor.

Por Vogelmeier, C, Hubbard, R C, Fells, G A, Schnebli, H P, Thompson, R C, Fritz, H, Crystal, R G
Publicado em 1991

Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.

Por Buhl, R, Vogelmeier, C, Critenden, M, Hubbard, R C, Hoyt, R F, Wilson, E M, Cantin, A M, Crystal, R G
Publicado em 1990

Expression of the secretory leukoprotease inhibitor gene in epithelial cells.

Por Abe, T, Kobayashi, N, Yoshimura, K, Trapnell, B C, Kim, H, Hubbard, R C, Brewer, M T, Thompson, R C, Crystal, R G
Publicado em 1991