Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.

Eitemau Tebyg

• Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.
  gan: Hubbard, R C, et al.
  Cyhoeddwyd: (1987)
• Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.
  gan: Ogushi, F, et al.
  Cyhoeddwyd: (1987)
• Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.
  gan: Ogushi, F, et al.
  Cyhoeddwyd: (1991)
• Role of alveolar macrophages in lipopolysaccharide-induced neutrophil accumulation.
  gan: Harmsen, A G
  Cyhoeddwyd: (1988)
• Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects.
  gan: Gadek, J E, et al.
  Cyhoeddwyd: (1981)