Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.

The emphysema of alpha 1-antitrypsin (alpha 1AT) deficiency is conceptualized to result from insufficient alpha 1AT allowing neutrophil elastase to destroy lung parenchyma. In addition to the deficiency of alpha 1AT in these individuals resulting from mutations in the alpha 1AT gene, it is recognize...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Hubbard, R C, Fells, G, Gadek, J, Pacholok, S, Humes, J, Crystal, R G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295476/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1653278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115391
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