Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.

Ítems similars

• Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.
  per: Ogushi, F, et al.
  Publicat: (1987)
• Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.
  per: Hubbard, R C, et al.
  Publicat: (1987)
• Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele.
  per: Curiel, D T, et al.
  Publicat: (1990)
• SP-A binds alpha(1)-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase
  per: Gorrini, Marina, et al.
  Publicat: (2005)
• Neutrophil Elastase Contributes to Cigarette Smoke-Induced Emphysema in Mice
  per: Shapiro, Steven D., et al.
  Publicat: (2003)