Chemically modified peptides and proteins - critical considerations for oral delivery

par Buckley, Stephen T., Hubálek, František, Rahbek, Ulrik Lytt
Publié dans Tissue Barriers (2016)

Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures

par Binda, Claudia, Li, Min, Hubálek, Frantisek, Restelli, Nadia, Edmondson, Dale E., Mattevi, Andrea
Publié 2003

Investigation of the Physico-Chemical Properties that Enable Co-Formulation of Basal Insulin Degludec with Fast-Acting Insulin Aspart

par Havelund, Svend, Ribel, Ulla, Hubálek, František, Hoeg-Jensen, Thomas, Wahlund, Per-Olof, Jonassen, Ib
Publié dans Pharm Res (2015)

Binding of Rasagiline-related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis

par Binda, Claudia, Hubálek, Frantisek, Li, Min, Herzig, Yaacov, Sterling, Jeffrey, Edmondson, Dale E., Mattevi, Andrea
Publié 2005

WD40 Repeat Proteins Striatin and S/G(2) Nuclear Autoantigen Are Members of a Novel Family of Calmodulin-binding Proteins That Associate with Protein Phosphatase 2A

par Moreno, Carlos S., Park, Susan, Nelson, Kasey, Ashby, Danita, Hubalek, Frantisek, Lane, William S., Pallas, David C.
Publié 2000

cAMP-Dependent Protein Kinase Inhibits mGluR2 Coupling to G-Proteins by Direct Receptor Phosphorylation

par Schaffhauser, Hervé, Cai, Zhaohui, Hubalek, Frantisek, Macek, Thomas A., Pohl, Jan, Murphy, Thomas J., Conn, P. Jeffrey
Publié dans J Neurosci (2000)

Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability

par Vinther, Tine N, Pettersson, Ingrid, Huus, Kasper, Schlein, Morten, Steensgaard, Dorte B, Sørensen, Anders, Jensen, Knud J, Kjeldsen, Thomas, Hubalek, František
Publié dans Protein Sci (2015)

Novel Covalently Linked Insulin Dimer Engineered to Investigate the Function of Insulin Dimerization

par Vinther, Tine N., Norrman, Mathias, Strauss, Holger M., Huus, Kasper, Schlein, Morten, Pedersen, Thomas Å., Kjeldsen, Thomas, Jensen, Knud J., Hubálek, František
Publié 2012

Dually Reactive Long Recombinant Linkers for Bioconjugations as an Alternative to PEG

par Kjeldsen, Thomas, Hogendorf, Wouter F. J., Tornøe, Christian W., Anderson, Jonathan, Hubalek, Frantisek, Stidsen, Carsten E., Sorensen, Jan L., Hoeg-Jensen, Thomas
Publié dans ACS Omega (2020)

Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors

par Cai, Zhaohui, Saugstad, Julie A., Sorensen, Scott D., Ciombor, Kelly J., Zhang, Congxiao, Schaffhauser, Hervé, Hubalek, Frantisek, Pohl, Jan, Duvoisin, Robert M., Conn, P. Jeffrey
Publié 2001

Insulin analog with additional disulfide bond has increased stability and preserved activity

par Vinther, Tine N, Norrman, Mathias, Ribel, Ulla, Huus, Kasper, Schlein, Morten, Steensgaard, Dorte B, Pedersen, Thomas Å, Pettersson, Ingrid, Ludvigsen, Svend, Kjeldsen, Thomas, Jensen, Knud J, Hubálek, František
Publié 2013

An ingestible self-orienting system for oral delivery of macromolecules

par Abramson, Alex, Caffarel-Salvador, Ester, Khang, Minsoo, Dellal, David, Silverstein, David, Gao, Yuan, Frederiksen, Morten Revsgaard, Vegge, Andreas, Hubálek, Frantisek, Water, Jorrit J., Friderichsen, Anders V., Fels, Johannes, Kirk, Rikke Kaae, Cleveland, Cody, Collins, Joy, Tamang, Siddartha, Hayward, Alison, Landh, Tomas, Buckley, Stephen T., Roxhed, Niclas, Rahbek, Ulrik, Langer, Robert, Traverso, Giovanni
Publié dans Science (2019)

Molecular engineering of safe and efficacious oral basal insulin

par Hubálek, Frantisek, Refsgaard, Hanne H. F., Gram-Nielsen, Sanne, Madsen, Peter, Nishimura, Erica, Münzel, Martin, Brand, Christian Lehn, Stidsen, Carsten Enggaard, Claussen, Christian Hove, Wulff, Erik Max, Pridal, Lone, Ribel, Ulla, Kildegaard, Jonas, Porsgaard, Trine, Johansson, Eva, Steensgaard, Dorte Bjerre, Hovgaard, Lars, Glendorf, Tine, Hansen, Bo Falck, Jensen, Maja Kirkegaard, Nielsen, Peter Kresten, Ludvigsen, Svend, Rugh, Susanne, Garibay, Patrick W., Moore, Mary Courtney, Cherrington, Alan D., Kjeldsen, Thomas
Publié dans Nat Commun (2020)

Author Correction: Molecular engineering of safe and efficacious oral basal insulin

par Hubálek, Frantisek, Refsgaard, Hanne H. F., Gram-Nielsen, Sanne, Madsen, Peter, Nishimura, Erica, Münzel, Martin, Brand, Christian Lehn, Stidsen, Carsten Enggaard, Claussen, Christian Hove, Wulff, Erik Max, Pridal, Lone, Ribel, Ulla, Kildegaard, Jonas, Porsgaard, Trine, Johansson, Eva, Steensgaard, Dorte Bjerre, Hovgaard, Lars, Glendorf, Tine, Hansen, Bo Falck, Jensen, Maja Kirkegaard, Nielsen, Peter Kresten, Ludvigsen, Svend, Rugh, Susanne, Garibay, Patrick W., Moore, Mary Courtney, Cherrington, Alan D., Kjeldsen, Thomas
Publié dans Nat Commun (2020)