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Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures
Monoamine oxidase B (MAO-B) is an outer mitochondrial membrane-bound enzyme that catalyzes the oxidative deamination of arylalkylamine neurotransmitters and has been a target for a number of clinically used drug inhibitors. The 1.7-Å structure of the reversible isatin–MAO-B complex has been determin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC187837/ https://ncbi.nlm.nih.gov/pubmed/12913124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1633804100 |
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