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Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Antidiabetes Drugs
[Image: see text] The widely employed antidiabetic drug pioglitazone (Actos) is shown to be a specific and reversible inhibitor of human monoamine oxidase B (MAO B). The crystal structure of the enzyme–inhibitor complex shows that the R-enantiomer is bound with the thiazolidinedione ring near the fl...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American
Chemical Society
2011
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263826/ https://ncbi.nlm.nih.gov/pubmed/22282722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200196p |
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