Pathogenic mechanisms: a rational basis for treatment

Por Howarth, Peter H
Publicado em 1998

Comparison of whole-blood eosinophil counts in extrinsic asthmatics with acute and chronic asthma

Por Howarth, Peter H
Publicado em 1982

A review of the tolerability and safety of levocabastine eye drops and nasal spray. Implications for patient management

Por Howarth, Peter H.
Publicado em 1995

A new look at the pathogenesis of asthma

Por Holgate, Stephen T., Arshad, Hasan S., Roberts, Graham C., Howarth, Peter H., Thurner, Philipp, Davies, Donna E.
Publicado em 2009

Airway Surfactant Protein D Deficiency in Adults With Severe Asthma

Por Mackay, Rose-Marie A., Grainge, Christopher L., Lau, Laurie C., Barber, Clair, Clark, Howard W., Howarth, Peter H.
Publicado no Chest (2016)

Regulation of A Disintegrin And Metalloprotease-33 Expression by Transforming Growth Factor-β

Por Yang, Youwen, Wicks, James, Haitchi, Hans Michael, Powell, Robert M., Manuyakorn, Wiparat, Howarth, Peter H., Holgate, Stephen T., Davies, Donna E.
Publicado em 2012

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

Por Manuyakorn, Wiparat, Smart, David E., Noto, Antonio, Bucchieri, Fabio, Haitchi, Hans Michael, Holgate, Stephen T., Howarth, Peter H., Davies, Donna E.
Publicado no PLoS One (2016)

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

Por Singhania, Akul, Rupani, Hitasha, Jayasekera, Nivenka, Lumb, Simon, Hales, Paul, Gozzard, Neil, Davies, Donna E., Woelk, Christopher H., Howarth, Peter H.
Publicado no PLoS One (2017)

Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response

Por Bedke, Nicole, Sammut, David, Green, Ben, Kehagia, Valia, Dennison, Patrick, Jenkins, Gisli, Tatler, Amanda, Howarth, Peter H., Holgate, Stephen T., Davies, Donna E.
Publicado em 2012

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

Por Green, Benjamin J., Wiriyachaiporn, Surasa, Grainge, Christopher, Rogers, Geraint B., Kehagia, Valia, Lau, Laurie, Carroll, Mary P., Bruce, Kenneth D., Howarth, Peter H.
Publicado em 2014

Proof of concept pilot study: prevalence of grass virus infection and the potential for effects on the allergenic potency of pollen

Por Pallett, Denise W, Soh, Emily, Edwards, Mary-Lou, Bodey, Kathleen, Lau, Laurie CK, Cooper, J Ian, Howarth, Peter H, Walls, Andrew F, Wang, Hui
Publicado em 2009

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life

Por Davies, Elizabeth R., Kelly, Joanne F.C., Howarth, Peter H., Wilson, David I., Holgate, Stephen T., Davies, Donna E., Whitsett, Jeffrey A., Haitchi, Hans Michael
Publicado no JCI Insight (2016)

Airway Epithelial Transcription Factor NK2 Homeobox 1 Inhibits Mucous Cell Metaplasia and Th2 Inflammation

Por Maeda, Yutaka, Chen, Gang, Xu, Yan, Haitchi, Hans Michael, Du, Lingling, Keiser, Angela R., Howarth, Peter H., Davies, Donna E., Holgate, Stephen T., Whitsett, Jeffrey A.
Publicado em 2011

A MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells

Por Martinez-Nunez, Rocio T., Bondanese, Victor P., Louafi, Fethi, Francisco-Garcia, Ana S., Rupani, Hitasha, Bedke, Nicole, Holgate, Stephen, Howarth, Peter H., Davies, Donna E., Sanchez-Elsner, Tilman
Publicado em 2014

Toll-like Receptor 7 Is Reduced in Severe Asthma and Linked to an Altered MicroRNA Profile

Por Rupani, Hitasha, Martinez-Nunez, Rocio T., Dennison, Patrick, Lau, Laurie C. K., Jayasekera, Nivenka, Havelock, Tom, Francisco-Garcia, Ana S., Grainge, Christopher, Howarth, Peter H., Sanchez-Elsner, Tilman
Publicado no Am J Respir Crit Care Med (2016)

Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial

Por Storrar, Will, Fogg, Carole, Brown, Tom, Dennison, Paddy, Yu, Ly-Mee, Dewey, Ann, Luengo-Fernandez, Ramon, Dean, Tara, Rahman, Najib, Mansur, Adel, Howarth, Peter H., Bradding, Peter, Chauhan, Anoop J.
Publicado no Trials (2016)

Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors

Por Leino, Marina S., Loxham, Matthew, Blume, Cornelia, Swindle, Emily J., Jayasekera, Nivenka P., Dennison, Patrick W., Shamji, Betty W. H., Edwards, Matthew J., Holgate, Stephen T., Howarth, Peter H., Davies, Donna E.
Publicado em 2013

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit

Por Hill, Alison R., Donaldson, Jessica E., Blume, Cornelia, Smithers, Natalie, Tezera, Liku, Tariq, Kamran, Dennison, Patrick, Rupani, Hitasha, Edwards, Matthew J., Howarth, Peter H., Grainge, Christopher, Davies, Donna E., Swindle, Emily J.
Publicado no Tissue Barriers (2016)

The Effects on Bronchial Epithelial Mucociliary Cultures of Coarse, Fine, and Ultrafine Particulate Matter From an Underground Railway Station

Por Loxham, Matthew, Morgan-Walsh, Rebecca J., Cooper, Matthew J., Blume, Cornelia, Swindle, Emily J., Dennison, Patrick W., Howarth, Peter H., Cassee, Flemming R., Teagle, Damon A. H., Palmer, Martin R., Davies, Donna E.
Publicado no Toxicol Sci (2015)

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

Por Hinks, Timothy S.C., Brown, Tom, Lau, Laurie C.K., Rupani, Hitasha, Barber, Clair, Elliott, Scott, Ward, Jon A., Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, Djukanović, Ratko, Kurukulaaratchy, Ramesh J., Chauhan, Anoop, Howarth, Peter H.
Publicado no J Allergy Clin Immunol (2016)