Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

BACKGROUND: Disease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood. OBJECTIVE: We aimed to identify and replicate clinicopathologic endotypes based on analysis of blood and sputum parameters in asthmatic patients. METHODS: One hu...

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Gepubliceerd in:J Allergy Clin Immunol
Hoofdauteurs: Hinks, Timothy S.C., Brown, Tom, Lau, Laurie C.K., Rupani, Hitasha, Barber, Clair, Elliott, Scott, Ward, Jon A., Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, Djukanović, Ratko, Kurukulaaratchy, Ramesh J., Chauhan, Anoop, Howarth, Peter H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mosby 2016
Onderwerpen:
Asthma and Lower Airway Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929135/
https://ncbi.nlm.nih.gov/pubmed/26851968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.11.020
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