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Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

BACKGROUND: Disease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood. OBJECTIVE: We aimed to identify and replicate clinicopathologic endotypes based on analysis of blood and sputum parameters in asthmatic patients. METHODS: One hu...

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Τόπος έκδοσης:	J Allergy Clin Immunol
Κύριοι συγγραφείς:	Hinks, Timothy S.C., Brown, Tom, Lau, Laurie C.K., Rupani, Hitasha, Barber, Clair, Elliott, Scott, Ward, Jon A., Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, Djukanović, Ratko, Kurukulaaratchy, Ramesh J., Chauhan, Anoop, Howarth, Peter H.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Mosby 2016
Θέματα:	Asthma and Lower Airway Disease
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4929135/ https://ncbi.nlm.nih.gov/pubmed/26851968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.11.020
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Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

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