Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

BACKGROUND: Disease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood. OBJECTIVE: We aimed to identify and replicate clinicopathologic endotypes based on analysis of blood and sputum parameters in asthmatic patients. METHODS: One hu...

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Detalles Bibliográficos
Publicado en:J Allergy Clin Immunol
Main Authors: Hinks, Timothy S.C., Brown, Tom, Lau, Laurie C.K., Rupani, Hitasha, Barber, Clair, Elliott, Scott, Ward, Jon A., Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, Djukanović, Ratko, Kurukulaaratchy, Ramesh J., Chauhan, Anoop, Howarth, Peter H.
Formato: Artigo
Idioma:Inglês
Publicado: Mosby 2016
Assuntos:
Asthma and Lower Airway Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929135/
https://ncbi.nlm.nih.gov/pubmed/26851968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.11.020
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