Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-γ(high) immunophenotypes: Potential benefits of calcitriol

BACKGROUND: A small population of patients with severe asthma does not respond to glucocorticoids (steroid resistant [SR]). They have high morbidity, highlighting an urgent need for strategies to enhance glucocorticoid responsiveness. OBJECTIVE: We investigated the immunologic differences between st...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Chambers, Emma S., Nanzer, Alexandra M., Pfeffer, Paul E., Richards, David F., Timms, Peter M., Martineau, Adrian R., Griffiths, Christopher J., Corrigan, Christopher J., Hawrylowicz, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mosby 2015
Assuntos:
Asthma and Lower Airway Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559139/
https://ncbi.nlm.nih.gov/pubmed/25772594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.01.026
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