Site-Specific Integration of an Adeno-Associated Virus Vector Plasmid Mediated by Regulated Expression of Rep Based on Cre-loxP Recombination

Por Satoh, Wataru, Hirai, Yukihiko, Tamayose, Kenji, Shimada, Takashi
Publicado em 2000

Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF

Por Yamazaki, Yoshiyuki, Hirai, Yukihiko, Miyake, Koichi, Shimada, Takashi
Publicado em 2014

Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector

Por Hironaka, Kohei, Yamazaki, Yoshiyuki, Hirai, Yukihiko, Yamamoto, Motoko, Miyake, Noriko, Miyake, Koichi, Okada, Takashi, Morita, Akio, Shimada, Takashi
Publicado no Sci Rep (2015)

Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1)

Por Tomono, Taro, Hirai, Yukihiko, Okada, Hironori, Adachi, Kumi, Ishii, Akiko, Shimada, Takashi, Onodera, Masafumi, Tamaoka, Akira, Okada, Takashi
Publicado no Mol Ther Methods Clin Dev (2016)

Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer

Por Takahashi, Hiroshi, Hirai, Yukihiko, Migita, Makoto, Seino, Yoshihiko, Fukuda, Yuh, Sakuraba, Hitoshi, Kase, Ryoichi, Kobayashi, Toshihide, Hashimoto, Yasuhiro, Shimada, Takashi
Publicado em 2002

Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection

Por Kashiwakura, Yuji, Tamayose, Kenji, Iwabuchi, Kazuhisa, Hirai, Yukihiko, Shimada, Takashi, Matsumoto, Kunio, Nakamura, Toshikazu, Watanabe, Masami, Oshimi, Kazuo, Daida, Hiroyuki
Publicado em 2005

Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice

Por Machida, Akira, Kuwahara, Hiroya, Mayra, Azat, Kubodera, Takayuki, Hirai, Takashi, Sunaga, Fumiko, Tajiri, Mio, Hirai, Yukihiko, Shimada, Takashi, Mizusawa, Hidehiro, Yokota, Takanori
Publicado em 2013

Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation

Por Igarashi, Tsutomu, Miyake, Koichi, Kobayashi, Maika, Kameya, Shuhei, Fujimoto, Chiaki, Nakamoto, Kenji, Takahashi, Hisatomo, Igarashi, Toru, Miyake, Noriko, Iijima, Osamu, Hirai, Yukihiko, Shimada, Takashi, Okada, Takashi, Takahashi, Hiroshi
Publicado no Mol Vis (2016)

Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9

Por Tomono, Taro, Hirai, Yukihiko, Okada, Hironori, Miyagawa, Yoshitaka, Adachi, Kumi, Sakamoto, Shuhei, Kawano, Yasuhiro, Chono, Hideto, Mineno, Junichi, Ishii, Akiko, Shimada, Takashi, Onodera, Masafumi, Tamaoka, Akira, Okada, Takashi
Publicado no Mol Ther Methods Clin Dev (2018)

Intrathecal AAV Serotype 9-mediated Delivery of shRNA Against TRPV1 Attenuates Thermal Hyperalgesia in a Mouse Model of Peripheral Nerve Injury

Por Hirai, Takashi, Enomoto, Mitsuhiro, Kaburagi, Hidetoshi, Sotome, Shinichi, Yoshida-Tanaka, Kie, Ukegawa, Madoka, Kuwahara, Hiroya, Yamamoto, Mariko, Tajiri, Mio, Miyata, Haruka, Hirai, Yukihiko, Tominaga, Makoto, Shinomiya, Kenichi, Mizusawa, Hidehiro, Okawa, Atsushi, Yokota, Takanori
Publicado em 2014

Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector

Por Nakamura-Takahashi, Aki, Miyake, Koichi, Watanabe, Atsushi, Hirai, Yukihiko, Iijima, Osamu, Miyake, Noriko, Adachi, Kumi, Nitahara-Kasahara, Yuko, Kinoshita, Hideaki, Noguchi, Taku, Abe, Shinichi, Narisawa, Sonoko, Millán, Jose Luis, Shimada, Takashi, Okada, Takashi
Publicado no Mol Ther Methods Clin Dev (2016)

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43

Por Uchida, Azusa, Sasaguri, Hiroki, Kimura, Nobuyuki, Tajiri, Mio, Ohkubo, Takuya, Ono, Fumiko, Sakaue, Fumika, Kanai, Kazuaki, Hirai, Takashi, Sano, Tatsuhiko, Shibuya, Kazumoto, Kobayashi, Masaki, Yamamoto, Mariko, Yokota, Shigefumi, Kubodera, Takayuki, Tomori, Masaki, Sakaki, Kyohei, Enomoto, Mitsuhiro, Hirai, Yukihiko, Kumagai, Jiro, Yasutomi, Yasuhiro, Mochizuki, Hideki, Kuwabara, Satoshi, Uchihara, Toshiki, Mizusawa, Hidehiro, Yokota, Takanori
Publicado em 2012