Intrathecal AAV Serotype 9-mediated Delivery of shRNA Against TRPV1 Attenuates Thermal Hyperalgesia in a Mouse Model of Peripheral Nerve Injury

Gene therapy for neuropathic pain requires efficient gene delivery to both central and peripheral nervous systems. We previously showed that an adenoassociated virus serotype 9 (AAV9) vector expressing short-hairpin RNA (shRNA) could suppress target molecule expression in the dorsal root ganglia (DR...

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Bibliographische Detailangaben
Hauptverfasser: Hirai, Takashi, Enomoto, Mitsuhiro, Kaburagi, Hidetoshi, Sotome, Shinichi, Yoshida-Tanaka, Kie, Ukegawa, Madoka, Kuwahara, Hiroya, Yamamoto, Mariko, Tajiri, Mio, Miyata, Haruka, Hirai, Yukihiko, Tominaga, Makoto, Shinomiya, Kenichi, Mizusawa, Hidehiro, Okawa, Atsushi, Yokota, Takanori
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916042/
https://ncbi.nlm.nih.gov/pubmed/24322332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.247
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