Human and Plant Fungal Pathogens: The Role of Secondary Metabolites

por Scharf, Daniel H., Heinekamp, Thorsten, Brakhage, Axel A.
Publicado 2014

Heptahelical Receptors GprC and GprD of Aspergillus fumigatus Are Essential Regulators of Colony Growth, Hyphal Morphogenesis, and Virulence

por Gehrke, Alexander, Heinekamp, Thorsten, Jacobsen, Ilse D., Brakhage, Axel A.
Publicado 2010

Protein Kinase A Regulates Growth, Sporulation, and Pigment Formation in Aspergillus fumigatus

por Grosse, Christina, Heinekamp, Thorsten, Kniemeyer, Olaf, Gehrke, Alexander, Brakhage, Axel A.
Publicado 2008

Heavy Metal-Induced Expression of PcaA Provides Cadmium Tolerance to Aspergillus fumigatus and Supports Its Virulence in the Galleria mellonella Model

por Bakti, Fruzsina, Sasse, Christoph, Heinekamp, Thorsten, Pócsi, István, Braus, Gerhard H.
Publicado en Front Microbiol (2018)

Systems Biology of Fungal Infection

por Horn, Fabian, Heinekamp, Thorsten, Kniemeyer, Olaf, Pollmächer, Johannes, Valiante, Vito, Brakhage, Axel A.
Publicado 2012

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence

por Heinekamp, Thorsten, Thywißen, Andreas, Macheleidt, Juliane, Keller, Sophia, Valiante, Vito, Brakhage, Axel A.
Publicado 2013

Characterization of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and their impact on virulence

por Lapp, Katrin, Vödisch, Martin, Kroll, Kristin, Strassburger, Maria, Kniemeyer, Olaf, Heinekamp, Thorsten, Brakhage, Axel A.
Publicado 2014

Production of Pyomelanin, a Second Type of Melanin, via the Tyrosine Degradation Pathway in Aspergillus fumigatus

por Schmaler-Ripcke, Jeannette, Sugareva, Venelina, Gebhardt, Peter, Winkler, Robert, Kniemeyer, Olaf, Heinekamp, Thorsten, Brakhage, Axel A.
Publicado 2009

CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicum

por Valente, Silvia, Piombo, Edoardo, Schroeckh, Volker, Meloni, Giovanna Roberta, Heinekamp, Thorsten, Brakhage, Axel A., Spadaro, Davide
Publicado en Front Microbiol (2021)

Pyomelanin Formation in Aspergillus fumigatus Requires HmgX and the Transcriptional Activator HmgR but Is Dispensable for Virulence

por Keller, Sophia, Macheleidt, Juliane, Scherlach, Kirstin, Schmaler-Ripcke, Jeannette, Jacobsen, Ilse D., Heinekamp, Thorsten, Brakhage, Axel A.
Publicado 2011

Genetic Engineering Activates Biosynthesis of Aromatic Fumaric Acid Amides in the Human Pathogen Aspergillus fumigatus

por Kalb, Daniel, Heinekamp, Thorsten, Lackner, Gerald, Scharf, Daniel H., Dahse, Hans-Martin, Brakhage, Axel A., Hoffmeister, Dirk
Publicado en Appl Environ Microbiol (2015)

Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway

por Thywißen, Andreas, Heinekamp, Thorsten, Dahse, Hans-Martin, Schmaler-Ripcke, Jeannette, Nietzsche, Sandor, Zipfel, Peter F., Brakhage, Axel A.
Publicado 2011

N‐Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

por Scharf, Daniel H., Chankhamjon, Pranatchareeya, Scherlach, Kirstin, Dworschak, Jan, Heinekamp, Thorsten, Roth, Martin, Brakhage, Axel A., Hertweck, Christian
Publicado en Chembiochem (2020)

The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus

por Jain, Radhika, Valiante, Vito, Remme, Nicole, Docimo, Teresa, Heinekamp, Thorsten, Hertweck, Christian, Gershenzon, Jonathan, Haas, Hubertus, Brakhage, Axel A
Publicado 2011

Interference of Aspergillus fumigatus with the immune response

por Heinekamp, Thorsten, Schmidt, Hella, Lapp, Katrin, Pähtz, Vera, Shopova, Iordana, Köster-Eiserfunke, Nora, Krüger, Thomas, Kniemeyer, Olaf, Brakhage, Axel A.
Publicado en Semin Immunopathol (2014)

The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus

por Frawley, Dean, Stroe, Maria C., Oakley, Berl R., Heinekamp, Thorsten, Straßburger, Maria, Fleming, Alastair B., Brakhage, Axel A., Bayram, Özgür
Publicado en Front Microbiol (2020)

Activity and Safety of Inhaled Itraconazole Nanosuspension in a Model Pulmonary Aspergillus fumigatus Infection in Inoculated Young Quails

por Wlaź, Piotr, Knaga, Sebastian, Kasperek, Kornel, Wlaź, Aleksandra, Poleszak, Ewa, Jeżewska-Witkowska, Grażyna, Winiarczyk, Stanisław, Wyska, Elżbieta, Heinekamp, Thorsten, Rundfeldt, Chris
Publicado en Mycopathologia (2015)

Proteomics of Aspergillus fumigatus Conidia-containing Phagolysosomes Identifies Processes Governing Immune Evasion

por Schmidt, Hella, Vlaic, Sebastian, Krüger, Thomas, Schmidt, Franziska, Balkenhol, Johannes, Dandekar, Thomas, Guthke, Reinhard, Kniemeyer, Olaf, Heinekamp, Thorsten, Brakhage, Axel A.
Publicado en Mol Cell Proteomics (2018)

The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus

por Hillmann, Falk, Bagramyan, Karine, Straßburger, Maria, Heinekamp, Thorsten, Hong, Teresa B., Bzymek, Krzysztof P., Williams, John C., Brakhage, Axel A., Kalkum, Markus
Publicado en Sci Rep (2016)

SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus

por Jöhnk, Bastian, Bayram, Özgür, Abelmann, Anja, Heinekamp, Thorsten, Mattern, Derek J., Brakhage, Axel A., Jacobsen, Ilse D., Valerius, Oliver, Braus, Gerhard H.
Publicado en PLoS Pathog (2016)