Immune monitoring technology primer: Single Cell Network Profiling (SCNP)

Por Hawtin, Rachael E., Cesano, Alessandra
Publicado no J Immunother Cancer (2015)

Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line

Por Chen, Rong, Chubb, Sherri, Cheng, Tiewei, Hawtin, Rachael E, Gandhi, Varsha, Plunkett, William
Publicado em 2010

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks

Por Hawtin, Rachael Elizabeth, Stockett, David Elliot, Wong, Oi Kwan, Lundin, Cecilia, Helleday, Thomas, Fox, Judith Ann
Publicado em 2010

Inter-donor variation in cell subset specific immune signaling responses in healthy individuals

Por Longo, Diane M, Louie, Brent, Wang, Ena, Pos, Zoltan, Marincola, Francesco M, Hawtin, Rachael E, Cesano, Alessandra
Publicado em 2012

SCNP identifies CLL donor subgroups by profiling functional immune signaling in the context of immune modulatory receptor expression

Por Le Scolan, Erwan, Fanton, Christie, Conroy, Andy, Tai, Albert, Tan, Nguyen, Louie, Brent, Evensen, Erik, Hawtin, Rachael
Publicado no J Immunother Cancer (2015)

Racial differences in B cell receptor signaling pathway activation

Por Longo, Diane M, Louie, Brent, Mathi, Kavita, Pos, Zoltan, Wang, Ena, Hawtin, Rachael E, Marincola, Francesco M, Cesano, Alessandra
Publicado em 2012

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

Por Chen, Rong, Wierda, William G., Chubb, Sherri, Hawtin, Rachael E., Fox, Judith A., Keating, Michael J., Gandhi, Varsha, Plunkett, William
Publicado em 2009

Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo

Por Scatena, Caroline D., Kumer, Jeffrey L., Arbitrario, Jennifer P., Howlett, Anthony R., Hawtin, Rachael E., Fox, Judith A., Silverman, Jeffrey A.
Publicado em 2010

Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP)

Por Rosen, David B, Leung, Ling Y, Louie, Brent, Cordeiro, James A, Conroy, Andrew, Shapira, Iuliana, Fields, Scott Z, Cesano, Alessandra, Hawtin, Rachael E
Publicado em 2014

Single-Cell Network Profiling of Peripheral Blood Mononuclear Cells from Healthy Donors Reveals Age- and Race-Associated Differences in Immune Signaling Pathway Activation

Por Longo, Diane M., Louie, Brent, Putta, Santosh, Evensen, Erik, Ptacek, Jason, Cordeiro, James, Wang, Ena, Pos, Zoltan, Hawtin, Rachael E., Marincola, Francesco M., Cesano, Alessandra
Publicado em 2012

Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes

Por Sherry, Barbara, Jain, Preetesh, Chiu, Pui Yan, Leung, Ling, Allen, Steven L., Kolitz, Jonathan E., Rai, Kanti R., Barrientos, Jacquie, Liang, Spencer, Hawtin, Rachael, Chiorazzi, Nicholas
Publicado no Immunol Res (2015)

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

Por Hawtin, Rachael E., Stockett, David E., Byl, Jo Ann W., McDowell, Robert S., Tan, Nguyen, Arkin, Michelle R., Conroy, Andrew, Yang, Wenjin, Osheroff, Neil, Fox, Judith A.
Publicado em 2010

Functional Pathway Analysis Using SCNP of FLT3 Receptor Pathway Deregulation in AML Provides Prognostic Information Independent from Mutational Status

Por Cesano, Alessandra, Putta, Santosh, Rosen, David B., Cohen, Aileen C., Gayko, Urte, Mathi, Kavita, Woronicz, John, Hawtin, Rachael E., Cripe, Larry, Sun, Zhuoxin, Tallman, Martin S., Paietta, Elisabeth
Publicado em 2013

Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for clinical response biomarker identific...

Por Hotson, Drew, Alvarado, Ryan, Conroy, Andrew, Putta, Santosh, Simeone, Ester, Esposito, Assunta, Capone, Mariaelena, Madonna, Gabriele, Grimaldi, Antonio M, Rosen, David, Liang, Spencer, Cesano, Alessandra, Ascierto, Paolo A, Hawtin, Rachael
Publicado em 2013

AKT Signaling as a Novel Factor Associated with In Vitro Resistance of Human AML to Gemtuzumab Ozogamicin

Por Rosen, David B., Harrington, Kimberly H., Cordeiro, James A., Leung, Ling Y., Putta, Santosh, Lacayo, Norman, Laszlo, George S., Gudgeon, Chelsea J., Hogge, Donna E., Hawtin, Rachael E., Cesano, Alessandra, Walter, Roland B.
Publicado em 2013

Validation of biomarkers to predict response to immunotherapy in cancer: Volume II — clinical validation and regulatory considerations

Por Dobbin, Kevin K., Cesano, Alessandra, Alvarez, John, Hawtin, Rachael, Janetzki, Sylvia, Kirsch, Ilan, Masucci, Giuseppe V., Robbins, Paul B., Selvan, Senthamil R., Streicher, Howard Z., Zhang, Jenny, Butterfield, Lisa H., Thurin, Magdalena
Publicado no J Immunother Cancer (2016)

Validation of biomarkers to predict response to immunotherapy in cancer: Volume I — pre-analytical and analytical validation

Por Masucci, Giuseppe V., Cesano, Alessandra, Hawtin, Rachael, Janetzki, Sylvia, Zhang, Jenny, Kirsch, Ilan, Dobbin, Kevin K., Alvarez, John, Robbins, Paul B., Selvan, Senthamil R., Streicher, Howard Z., Butterfield, Lisa H., Thurin, Magdalena
Publicado no J Immunother Cancer (2016)

Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for response biomarker identification

Por Hotson, Drew, Alvarado, Ryan, Conroy, Andy, Putta, Santosh, Simeone, Ester, Esposito, Assunta, Capone, Mariaelena, Madonna, Gabriele, Grimaldi, Antonio M, Rosen, David B, Liang, Spencer, Cesano, Alessandra, Cacciapuoti, Carmela, Ascierto, Paolo A, Hawtin, Rachael E
Publicado em 2014

A phase 1b/2 study of vosaroxin in combination with cytarabine in patients with relapsed or refractory acute myeloid leukemia

Por Lancet, Jeffrey E., Roboz, Gail J., Cripe, Larry D., Michelson, Glenn C., Fox, Judith A., Leavitt, Richard D., Chen, Tianling, Hawtin, Rachael, Craig, Adam R., Ravandi, Farhad, Maris, Michael B., Stuart, Robert K., Karp, Judith E.
Publicado no Haematologica (2015)

High-dimensional analysis of the aging immune system: Verification of age-associated differences in immune signaling responses in healthy donors

Por Longo, Diane M, Louie, Brent, Ptacek, Jason, Friedland, Greg, Evensen, Erik, Putta, Santosh, Atallah, Michelle, Spellmeyer, David, Wang, Ena, Pos, Zoltan, Marincola, Francesco M, Schaeffer, Andrea, Lukac, Suzanne, Railkar, Radha, Beals, Chan R, Cesano, Alessandra, Carayannopoulos, Leonidas N, Hawtin, Rachael E
Publicado no J Transl Med (2014)