Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules

por Gunn, Richard M., Hailes, Helen C.
Publicado 2008

Identification and catalytic properties of new epoxide hydrolases from the genomic data of soil bacteria

por Stojanovski, Gorjan, Dobrijevic, Dragana, Hailes, Helen C., Ward, John M.
Publicado en Enzyme Microb Technol (2020)

Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines

por Lichman, Benjamin R., Zhao, Jianxiong, Hailes, Helen C., Ward, John M.
Publicado en Nat Commun (2017)

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues

por Zhao, Jianxiong, Lichman, Benjamin R., Ward, John M., Hailes, Helen C.
Publicado en Chem Commun (Camb) (2018)

Biomimetic Phosphate-Catalyzed Pictet–Spengler Reaction for the Synthesis of 1,1′-Disubstituted and Spiro-Tetrahydroisoquinoline Alkaloids

por Zhao, Jianxiong, Méndez-Sánchez, Daniel, Ward, John M., Hailes, Helen C.
Publicado en J Org Chem (2019)

Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations

por Foster, Robert W, Tame, Christopher J, Hailes, Helen C, Sheppard, Tom D
Publicado 2013

One–Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors

por Pesnot, Thomas, Gershater, Markus C., Edwards, Martin, Ward, John M., Hailes, Helen C.
Publicado en Molecules (2017)

Aminopolyols from Carbohydrates: Amination of Sugars and Sugar‐Derived Tetrahydrofurans with Transaminases

por Subrizi, Fabiana, Benhamou, Laure, Ward, John M., Sheppard, Tom D., Hailes, Helen C.
Publicado en Angew Chem Int Ed Engl (2019)

Regioselective Dehydration of Sugar Thioacetals under Mild Conditions

por Szpara, Rachel, Goyder, Alexander, Porter, Michael J., Hailes, Helen C., Sheppard, Tom D.
Publicado en Org Lett (2021)

Characterisation of a hyperthermophilic transketolase from Thermotoga maritima DSM3109 as a biocatalyst for 7-keto-octuronic acid synthesis

por Cárdenas-Fernández, Max, Subrizi, Fabiana, Dobrijevic, Dragana, Hailes, Helen C., Ward, John M.
Publicado en Org Biomol Chem (2021)

Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses

por Foster, Robert W, Tame, Christopher J, Bučar, Dejan-Krešimir, Hailes, Helen C, Sheppard, Tom D
Publicado en Chemistry (2015)

Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents

por Demetriou, Eleni, Story, Harriet E., Bofinger, Robin, Hailes, Helen C., Tabor, Alethea B., Golay, Xavier
Publicado en J Phys Chem B (2019)

Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes

por Affaticati, Pierre E., Dai, Shao-Bo, Payongsri, Panwajee, Hailes, Helen C., Tittmann, Kai, Dalby, Paul A.
Publicado en Sci Rep (2016)

Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase

por Lichman, Benjamin R., Sula, Altin, Pesnot, Thomas, Hailes, Helen C., Ward, John M., Keep, Nicholas H.
Publicado en Biochemistry (2017)

Data on a thermostable enzymatic one-pot reaction for the production of a high-value compound from l-arabinose

por Bawn, Maria, Subrizi, Fabiana, Lye, Gary J., Sheppard, Tom D., Hailes, Helen C., Ward, John M.
Publicado en Data Brief (2018)

A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks

por Popadić, Désirée, Mhaindarkar, Dipali, Dang Thai, Mike H. N., Hailes, Helen C., Mordhorst, Silja, Andexer, Jennifer N.
Publicado en RSC Chem Biol (2021)

The identification and use of robust transaminases from a domestic drain metagenome

por Leipold, Leona, Dobrijevic, Dragana, Jeffries, Jack W. E., Bawn, Maria, Moody, Thomas S., Ward, John M., Hailes, Helen C.
Publicado en Green Chem (2019)

Catalytic direct amidations in tert-butyl acetate using B(OCH(2)CF(3))(3)

por Coomber, Charlotte E., Laserna, Victor, Martin, Liam T., Smith, Peter D., Hailes, Helen C., Porter, Michael J., Sheppard, Tom D.
Publicado en Org Biomol Chem (2019)

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca

por Sayer, Christopher, Martinez-Torres, Ruben J, Richter, Nina, Isupov, Michail N, Hailes, Helen C, Littlechild, Jennifer A, Ward, John M
Publicado en FEBS J (2014)

Irreversible endo-Selective Diels–Alder Reactions of Substituted Alkoxyfurans: A General Synthesis of endo-Cantharimides

por Foster, Robert W, Benhamou, Laure, Porter, Michael J, Bučar, Dejan-Krešimir, Hailes, Helen C, Tame, Christopher J, Sheppard, Tom D
Publicado en Chemistry (2015)