Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

Por Zheng, C F, Guan, K L
Publicado em 1994

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation.

Por Sugimoto, T, Stewart, S, Han, M, Guan, K L
Publicado em 1998

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

Por Kang, Y J, Lu, M-K, Guan, K-L
Publicado em 2011

Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK

Por Xiong, Y., Lei, Q-Y., Zhao, S., Guan, K-L.
Publicado no Cold Spring Harb Symp Quant Biol (2011)

Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant.

Por Bliska, J B, Guan, K L, Dixon, J E, Falkow, S
Publicado em 1991

Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.

Por Millar, J B, Russell, P, Dixon, J E, Guan, K L
Publicado em 1992

Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK).

Por Pang, L, Zheng, C F, Guan, K L, Saltiel, A R
Publicado em 1995

Cloning and expression of a protein-tyrosine-phosphatase.

Por Guan, K L, Haun, R S, Watson, S J, Geahlen, R L, Dixon, J E
Publicado em 1990

Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.

Por Guan, K L, Jenkins, C W, Li, Y, O'Keefe, C L, Noh, S, Wu, X, Zariwala, M, Matera, A G, Xiong, Y
Publicado em 1996

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

Por Yang, H, Liu, Y, Bai, F, Zhang, J-Y, Ma, S-H, Liu, J, Xu, Z-D, Zhu, H-G, Ling, Z-Q, Ye, D, Guan, K-L, Xiong, Y
Publicado em 2012

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

Por Azad, T., Janse van Rensburg, H. J., Lightbody, E. D., Neveu, B., Champagne, A., Ghaffari, A., Kay, V. R., Hao, Y., Shen, H., Yeung, B., Croy, B. A., Guan, K. L., Pouliot, F., Zhang, J., Nicol, C. J. B., Yang, X.
Publicado no Nat Commun (2018)