A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component LATS kinase. Using this biosensor and a library o...

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Publicat a:Nat Commun
Autors principals: Azad, T., Janse van Rensburg, H. J., Lightbody, E. D., Neveu, B., Champagne, A., Ghaffari, A., Kay, V. R., Hao, Y., Shen, H., Yeung, B., Croy, B. A., Guan, K. L., Pouliot, F., Zhang, J., Nicol, C. J. B., Yang, X.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849716/
https://ncbi.nlm.nih.gov/pubmed/29535383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03278-w
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