The use of GEM models for experimental cancer therapeutics

Tekijä Gopinathan, Aarthi, Tuveson, David A.
Julkaistu 2008

GEMMs as preclinical models for testing pancreatic cancer therapies

Tekijä Gopinathan, Aarthi, Morton, Jennifer P., Jodrell, Duncan I., Sansom, Owen J.
Julkaisussa Dis Model Mech (2015)

The pancreas cancer microenvironment

Tekijä Feig, Christine, Gopinathan, Aarthi, Neesse, Albrecht, Chan, Derek S., Cook, Natalie, Tuveson, David A.
Julkaistu 2012

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

Tekijä Cook, Natalie, Frese, Kristopher K., Bapiro, Tashinga E., Jacobetz, Michael A., Gopinathan, Aarthi, Miller, Jodi L., Rao, Sudhir S., Demuth, Tim, Howat, William J., Jodrell, Duncan I., Tuveson, David A.
Julkaistu 2012

MRI with hyperpolarised [1-(13)C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model

Tekijä Serrao, Eva M, Kettunen, Mikko I, Rodrigues, Tiago B, Dzien, Piotr, Wright, Alan J, Gopinathan, Aarthi, Gallagher, Ferdia A, Lewis, David Y, Frese, Kristopher K, Almeida, Jaime, Howat, William J, Tuveson, David A, Brindle, Kevin M
Julkaisussa Gut (2016)

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Tekijä Cook, Natalie, Basu, Bristi, Smith, Donna-Michelle, Gopinathan, Aarthi, Evans, Jeffry, Steward, William P, Palmer, Daniel, Propper, David, Venugopal, Balaji, Hategan, Mirela, Anthoney, D Alan, Hampson, Lisa V, Nebozhyn, Michael, Tuveson, David, Farmer-Hall, Hayley, Turner, Helen, McLeod, Robert, Halford, Sarah, Jodrell, Duncan
Julkaisussa Br J Cancer (2018)

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Tekijä DeNicola, Gina M., Karreth, Florian A., Humpton, Timothy J., Gopinathan, Aarthi, Wei, Cong, Frese, Kristopher, Mangal, Dipti, Yu, Kenneth H., Yeo, Charles J., Calhoun, Eric S., Scrimieri, Francesca, Winter, Jordan M., Hruban, Ralph H., Iacobuzio-Donahue, Christine, Kern, Scott E., Blair, Ian A., Tuveson, David A.
Julkaistu 2011

mTORC2 signaling drives the development and progression of pancreatic cancer

Tekijä Driscoll, David R, Karim, Saadia A, Sano, Makoto, Gay, David M, Jacob, Wright, Yu, Jun, Mizukami, Yusuke, Gopinathan, Aarthi, Jodrell, Duncan I, Evans, TR Jeffry, Bardeesy, Nabeel, Hall, Michael N, Quattrochi, Brian J., Klimstra, David S., Barry, Simon T, Sansom, Owen J, Lewis, Brian C, Morton, Jennifer P
Julkaisussa Cancer Res (2016)

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response

Tekijä Biasci, Daniele, Smoragiewicz, Martin, Connell, Claire M., Wang, Zhikai, Gao, Ya, Thaventhiran, James E. D., Basu, Bristi, Magiera, Lukasz, Johnson, T. Isaac, Bax, Lisa, Gopinathan, Aarthi, Isherwood, Christopher, Gallagher, Ferdia A., Pawula, Maria, Hudecova, Irena, Gale, Davina, Rosenfeld, Nitzan, Barmpounakis, Petros, Popa, Elizabeta Cristina, Brais, Rebecca, Godfrey, Edmund, Mir, Fraz, Richards, Frances M., Fearon, Douglas T., Janowitz, Tobias, Jodrell, Duncan I.
Julkaisussa Proc Natl Acad Sci U S A (2020)

CSF1R(+) Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

Tekijä Candido, Juliana B., Morton, Jennifer P., Bailey, Peter, Campbell, Andrew D., Karim, Saadia A., Jamieson, Thomas, Lapienyte, Laura, Gopinathan, Aarthi, Clark, William, McGhee, Ewan J., Wang, Jun, Escorcio-Correia, Monica, Zollinger, Raphael, Roshani, Rozita, Drew, Lisa, Rishi, Loveena, Arkell, Rebecca, Evans, T.R. Jeffry, Nixon, Colin, Jodrell, Duncan I., Wilkinson, Robert W., Biankin, Andrew V., Barry, Simon T., Balkwill, Frances R., Sansom, Owen J.
Julkaisussa Cell Rep (2018)

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Tekijä Olive, Kenneth P., Jacobetz, Michael A., Davidson, Christian J., Gopinathan, Aarthi, McIntyre, Dominick, Honess, Davina, Madhu, Basetti, Goldgraben, Mae A., Caldwell, Meredith E., Allard, David, Frese, Kristopher K., DeNicola, Gina, Feig, Christine, Combs, Chelsea, Winter, Stephen P., Ireland, Heather, Reichelt, Stefanie, Howat, William J., Chang, Alex, Dhara, Mousumi, Wang, Lifu, Rückert, Felix, Grützmann, Robert, Pilarsky, Christian, Izeradjene, Kamel, Hingorani, Sunil R., Huang, Pearl, Davies, Susan E., Plunkett, William, Egorin, Merrill, Hruban, Ralph H., Whitebread, Nigel, McGovern, Karen, Adams, Julian, Iacobuzio-Donahue, Christine, Griffiths, John, Tuveson, David A.
Julkaistu 2009