Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis

Por Wang, David B., Gitcho, Michael A., Kraemer, Brian C., Klein, Ronald L.
Publicado em 2011

TDP-43 expression influences amyloid β plaque deposition and tau aggregation

Por Davis, Stephani A., Gan, Kok Ann, Dowell, James A., Cairns, Nigel J., Gitcho, Michael A.
Publicado no Neurobiol Dis (2017)

VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death

Por Gitcho, Michael A., Strider, Jeffrey, Carter, Deborah, Taylor-Reinwald, Lisa, Forman, Mark S., Goate, Alison M., Cairns, Nigel J.
Publicado em 2009

POTENTIATION OF INSULIN-STIMULATED GLUCOSE TRANSPORT BY THE AMP-ACTIVATED PROTEIN KINASE

Por Ju, Jeong-Sun, Gitcho, Michael A., Casmaer, Carter A., Patil, Pankaj B., Han, Dae-Gyue, Spencer, Susan A., Fisher, Jonathan S.
Publicado em 2006

TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics

Por Davis, Stephani A., Itaman, Sheed, Khalid-Janney, Christopher M., Sherard, Justin A., Dowell, James A., Cairns, Nigel J., Gitcho, Michael A.
Publicado no Neurosci Lett (2018)

Pathogenic Cysteine Mutations Affect Progranulin Function and Production of Mature Granulins

Por Wang, Jun, Van Damme, Philip, Cruchaga, Carlos, Gitcho, Michael A., Vidal, Jose Manuel, Seijo-Martínez, Manuel, Wang, Lei, Wu, Jane Y., Robberecht, Wim, Goate, Alison
Publicado em 2009

TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

Por Gitcho, Michael A., Bigio, Eileen H., Mishra, Manjari, Johnson, Nancy, Weintraub, Sandra, Mesulam, Marsel, Rademakers, Rosa, Chakraverty, Sumi, Cruchaga, Carlos, Morris, John C., Goate, Alison M., Cairns, Nigel J.
Publicado em 2009

FUS immunogold labelling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS prote...

Por Page, Tristan, Gitcho, Michael A., Mosaheb, Sabrina, Carter, Deborah, Chakraverty, Sumi, Perry, Robert H., Bigio, Eileen H., Gearing, Marla, Ferrer, Isidre, Goate, Alison M., Cairns, Nigel J., Thorpe, Julian R.
Publicado em 2011

Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis

Por Dayton, Robert D, Gitcho, Michael A, Orchard, Elysse A, Wilson, Jon D, Wang, David B, Cain, Cooper D, Johnson, Jeffrey A, Zhang, Yong-Jie, Petrucelli, Leonard, Mathis, J Michael, Klein, Ronald L
Publicado em 2013

Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates

Por Jackson, Kasey L., Dayton, Robert D., Fisher-Perkins, Jeanne M., Didier, Peter J., Baker, Kate C., Weimer, Maria, Gutierrez, Amparo, Cain, Cooper D., Mathis, J. Michael, Gitcho, Michael A., Bunnell, Bruce A., Klein, Ronald L.
Publicado no J Med Primatol (2015)

Molecular Characterization of Novel Progranulin (GRN) Mutations in Frontotemporal Dementia

Por Mukherjee, Odity, Wang, Jun, Gitcho, Michael, Chakraverty, Sumi, Taylor-Reinwald, Lisa, Shears, Shantia, Kauwe, John S.K., Norton, Joanne, Levitch, Denise, Bigio, Eileen H., Hatanpaa, Kimmo J., White, Charles L., Morris, John C., Cairns, Nigel J., Goate, Alison
Publicado em 2008

TDP-43 A315T Mutation in Familial Motor Neuron Disease

Por Gitcho, Michael A., Baloh, Robert H., Chakraverty, Sumi, Mayo, Kevin, Norton, Joanne B., Levitch, Denise, Hatanpaa, Kimmo J., White, Charles L., Bigio, Eileen H., Caselli, Richard, Baker, Matt, Al-Lozi, Muhammad T., Morris, John C., Pestronk, Alan, Rademakers, Rosa, Goate, Alison M., Cairns, Nigel J.
Publicado em 2008

HDDD2 Is a Familial Frontotemporal Lobar Degeneration with Ubiquitin-Positive, Tau-Negative Inclusions Caused by a Missense Mutation in the Signal Peptide of Progranulin

Por Mukherjee, Odity, Pastor, Pau, Cairns, Nigel J., Chakraverty, Sumi, Kauwe, John S. K., Shears, Shantia, Behrens, Maria I., Budde, John, Hinrichs, Anthony L., Norton, Joanne, Levitch, Denise, Taylor-Reinwald, Lisa, Gitcho, Michael, Tu, P.-H., Grinberg, Lea Tenenholz, Liscic, Rajka M., Armendariz, Javier, Morris, John C., Goate, Alison M.
Publicado em 2006

TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions

Por Cairns, Nigel J., Neumann, Manuela, Bigio, Eileen H., Holm, Ida E., Troost, Dirk, Hatanpaa, Kimmo J., Foong, Chan, White, Charles L., Schneider, Julie A., Kretzschmar, Hans A., Carter, Deborah, Taylor-Reinwald, Lisa, Paulsmeyer, Katherine, Strider, Jeffrey, Gitcho, Michael, Goate, Alison M., Morris, John C., Mishra, Manjari, Kwong, Linda K., Stieber, Anna, Xu, Yan, Forman, Mark S., Trojanowski, John Q., Lee, Virginia M.-Y., Mackenzie, Ian R.A.
Publicado em 2007