Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis

par Wang, David B., Gitcho, Michael A., Kraemer, Brian C., Klein, Ronald L.
Publié 2011

TDP-43 expression influences amyloid β plaque deposition and tau aggregation

par Davis, Stephani A., Gan, Kok Ann, Dowell, James A., Cairns, Nigel J., Gitcho, Michael A.
Publié dans Neurobiol Dis (2017)

VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death

par Gitcho, Michael A., Strider, Jeffrey, Carter, Deborah, Taylor-Reinwald, Lisa, Forman, Mark S., Goate, Alison M., Cairns, Nigel J.
Publié 2009

POTENTIATION OF INSULIN-STIMULATED GLUCOSE TRANSPORT BY THE AMP-ACTIVATED PROTEIN KINASE

par Ju, Jeong-Sun, Gitcho, Michael A., Casmaer, Carter A., Patil, Pankaj B., Han, Dae-Gyue, Spencer, Susan A., Fisher, Jonathan S.
Publié 2006

Hippocampal neurobiology and function in an aged mouse model of TDP-43 proteinopathy in an APP/PSEN1 background

par Arezoumandan, Sanaz, Cai, Xuezhu, Kalkarni, Praveen, Davis, Stephani A., Wilson, Katherine, Ferris, Craig F., Cairns, Nigel J., Gitcho, Michael A.
Publié dans Neurosci Lett (2021)

TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics

par Davis, Stephani A., Itaman, Sheed, Khalid-Janney, Christopher M., Sherard, Justin A., Dowell, James A., Cairns, Nigel J., Gitcho, Michael A.
Publié dans Neurosci Lett (2018)

Pathogenic Cysteine Mutations Affect Progranulin Function and Production of Mature Granulins

par Wang, Jun, Van Damme, Philip, Cruchaga, Carlos, Gitcho, Michael A., Vidal, Jose Manuel, Seijo-Martínez, Manuel, Wang, Lei, Wu, Jane Y., Robberecht, Wim, Goate, Alison
Publié 2009

TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

par Gitcho, Michael A., Bigio, Eileen H., Mishra, Manjari, Johnson, Nancy, Weintraub, Sandra, Mesulam, Marsel, Rademakers, Rosa, Chakraverty, Sumi, Cruchaga, Carlos, Morris, John C., Goate, Alison M., Cairns, Nigel J.
Publié 2009

FUS immunogold labelling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS prote...

par Page, Tristan, Gitcho, Michael A., Mosaheb, Sabrina, Carter, Deborah, Chakraverty, Sumi, Perry, Robert H., Bigio, Eileen H., Gearing, Marla, Ferrer, Isidre, Goate, Alison M., Cairns, Nigel J., Thorpe, Julian R.
Publié 2011

Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis

par Dayton, Robert D, Gitcho, Michael A, Orchard, Elysse A, Wilson, Jon D, Wang, David B, Cain, Cooper D, Johnson, Jeffrey A, Zhang, Yong-Jie, Petrucelli, Leonard, Mathis, J Michael, Klein, Ronald L
Publié 2013

Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates

par Jackson, Kasey L., Dayton, Robert D., Fisher-Perkins, Jeanne M., Didier, Peter J., Baker, Kate C., Weimer, Maria, Gutierrez, Amparo, Cain, Cooper D., Mathis, J. Michael, Gitcho, Michael A., Bunnell, Bruce A., Klein, Ronald L.
Publié dans J Med Primatol (2015)

Molecular Characterization of Novel Progranulin (GRN) Mutations in Frontotemporal Dementia

par Mukherjee, Odity, Wang, Jun, Gitcho, Michael, Chakraverty, Sumi, Taylor-Reinwald, Lisa, Shears, Shantia, Kauwe, John S.K., Norton, Joanne, Levitch, Denise, Bigio, Eileen H., Hatanpaa, Kimmo J., White, Charles L., Morris, John C., Cairns, Nigel J., Goate, Alison
Publié 2008

TDP-43 A315T Mutation in Familial Motor Neuron Disease

par Gitcho, Michael A., Baloh, Robert H., Chakraverty, Sumi, Mayo, Kevin, Norton, Joanne B., Levitch, Denise, Hatanpaa, Kimmo J., White, Charles L., Bigio, Eileen H., Caselli, Richard, Baker, Matt, Al-Lozi, Muhammad T., Morris, John C., Pestronk, Alan, Rademakers, Rosa, Goate, Alison M., Cairns, Nigel J.
Publié 2008

HDDD2 Is a Familial Frontotemporal Lobar Degeneration with Ubiquitin-Positive, Tau-Negative Inclusions Caused by a Missense Mutation in the Signal Peptide of Progranulin

par Mukherjee, Odity, Pastor, Pau, Cairns, Nigel J., Chakraverty, Sumi, Kauwe, John S. K., Shears, Shantia, Behrens, Maria I., Budde, John, Hinrichs, Anthony L., Norton, Joanne, Levitch, Denise, Taylor-Reinwald, Lisa, Gitcho, Michael, Tu, P.-H., Grinberg, Lea Tenenholz, Liscic, Rajka M., Armendariz, Javier, Morris, John C., Goate, Alison M.
Publié 2006

TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions

par Cairns, Nigel J., Neumann, Manuela, Bigio, Eileen H., Holm, Ida E., Troost, Dirk, Hatanpaa, Kimmo J., Foong, Chan, White, Charles L., Schneider, Julie A., Kretzschmar, Hans A., Carter, Deborah, Taylor-Reinwald, Lisa, Paulsmeyer, Katherine, Strider, Jeffrey, Gitcho, Michael, Goate, Alison M., Morris, John C., Mishra, Manjari, Kwong, Linda K., Stieber, Anna, Xu, Yan, Forman, Mark S., Trojanowski, John Q., Lee, Virginia M.-Y., Mackenzie, Ian R.A.
Publié 2007