Generation of Novel Pikromycin Antibiotic Products Through Mutasynthesis

Por Gupta, Shuchi, Lakshmanan, Venkatraman, Kim, Beom Seok, Fecik, Robert, Reynolds, Kevin A.
Publicado em 2008

A General Scheme for Synthesis of Substrate-based Polyketide Labels for Acyl Carrier Proteins

Por Leggans, Erick K., Akey, David L., Smith, Janet L., Fecik, Robert A.
Publicado em 2010

Total Synthesis and Biological Evaluation of Tubulysin U, Tubulysin V, and their Analogs

Por Balasubramanian, Ranganathan, Raghavan, Bhooma, Begaye, Adrian, Sackett, Dan L., Fecik, Robert A.
Publicado em 2009

Polyketide Intermediate Mimics as Probes for Revealing Cryptic Stereochemistry of Ketoreductase Domains

Por Li, Yang, Fiers, William D., Bernard, Steffen M., Smith, Janet L., Aldrich, Courtney C., Fecik, Robert A.
Publicado no ACS Chem Biol (2014)

Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates

Por Fiers, William D., Dodge, Greg J., Li, Yang, Smith, Janet L., Fecik, Robert A., Aldrich, Courtney C.
Publicado no Chem Sci (2015)

Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase

Por Li, Yang, Dodge, Greg J., Fiers, William D., Fecik, Robert A., Smith, Janet L., Aldrich, Courtney C.
Publicado no J Am Chem Soc (2015)

Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

Por Boger, Dale L., Sato, Haruhiko, Lerner, Aaron E., Hedrick, Michael P., Fecik, Robert A., Miyauchi, Hiroshi, Wilkie, Gordon D., Austin, Bryce J., Patricelli, Matthew P., Cravatt, Benjamin F.
Publicado em 2000

Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Por Boger, Dale L., Miyauchi, Hiroshi, Du, Wu, Hardouin, Christophe, Fecik, Robert A., Cheng, Heng, Hwang, Inkyu, Hedrick, Michael P., Leung, Donmienne, Acevedo, Orlando, Guimarães, Cristiano R. W., Jorgensen, William L., Cravatt, Benjamin F.
Publicado em 2005