Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor.

Por Escobedo, J A, Barr, P J, Williams, L T
Publicado em 1988

Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimu...

Por Fantl, W J, Escobedo, J A, Williams, L T
Publicado em 1989

Identification of Tyr-397 as the primary site of tyrosine phosphorylation and pp60src association in the focal adhesion kinase, pp125FAK.

Por Eide, B L, Turck, C W, Escobedo, J A
Publicado em 1995

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.

Por Klippel, A, Escobedo, J A, Hirano, M, Williams, L T
Publicado em 1994

A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.

Por Klippel, A, Escobedo, J A, Hu, Q, Williams, L T
Publicado em 1993

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor bet...

Por Klippel, A, Escobedo, J A, Fantl, W J, Williams, L T
Publicado em 1992

Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells.

Por Kavanaugh, W M, Klippel, A, Escobedo, J A, Williams, L T
Publicado em 1992

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.

Por Satoh, T, Fantl, W J, Escobedo, J A, Williams, L T, Kaziro, Y
Publicado em 1993

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine.

Por Escobedo, J A, Kaplan, D R, Kavanaugh, W M, Turck, C W, Williams, L T
Publicado em 1991

Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on t...

Por Kamohara, S, Hayashi, H, Todaka, M, Kanai, F, Ishii, K, Imanaka, T, Escobedo, J A, Williams, L T, Ebina, Y
Publicado em 1995

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.

Por Starksen, N F, Simpson, P C, Bishopric, N, Coughlin, S R, Lee, W M, Escobedo, J A, Williams, L T
Publicado em 1986

Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D.

Por Manning, W C, Paliard, X, Zhou, S, Pat Bland, M, Lee, A Y, Hong, K, Walker, C M, Escobedo, J A, Dwarki, V
Publicado em 1997