The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

Upon stimulation by its ligand, the platelet-derived growth factor (PDGF) receptor associates with the 85-kDa subunit of phosphatidylinositol (PI) 3-kinase. The 85-kDa protein (p85) contains two Src homology 2 (SH2) domains and one SH3 domain. To define the part of p85 that interacts with the PDGF r...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Klippel, A, Escobedo, J A, Fantl, W J, Williams, L T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369586/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1312663/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.4.1451-1459.1992
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