Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis.

Gelijkaardige items

• Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells.
  door: Kavanaugh, W M, et al.
  Gepubliceerd in: (1992)
• The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.
  door: Klippel, A, et al.
  Gepubliceerd in: (1992)
• Hearing loss leading to impaired ability to communicate in residents of homes for the elderly.
  door: Anand, J. K., et al.
  Gepubliceerd in: (1989)
• Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase.
  door: Downing, J R, et al.
  Gepubliceerd in: (1991)
• Ligand-Induced Conformational Changes: Improved Predictions of Ligand Binding Conformations and Affinities
  door: Frimurer, Thomas M., et al.
  Gepubliceerd in: (2003)