Targeting B-cell receptor signaling kinases in chronic lymphocytic leukemia: the promise of entospletinib

Por Sharman, Jeff, Di Paolo, Julie
Publicado no Ther Adv Hematol (2016)

Pharmacokinetics, Pharmacodynamics, and Safety of Entospletinib, a Novel pSYK Inhibitor, Following Single and Multiple Oral Dosing in Healthy Volunteers

Por Ramanathan, Srini, Di Paolo, Julie A., Jin, Feng, Shao, Lixin, Sharma, Shringi, Robeson, Michelle, Kearney, Brian P.
Publicado no Clin Drug Investig (2016)

Phase 2 study of idelalisib and entospletinib: pneumonitis limits combination therapy in relapsed refractory CLL and NHL

Por Barr, Paul M., Saylors, Gene B., Spurgeon, Stephen E., Cheson, Bruce D., Greenwald, Daniel R., O’Brien, Susan M., Liem, Andre K. D., Mclntyre, Rosemary E., Joshi, Adarsh, Abella-Dominicis, Esteban, Hawkins, Michael J., Reddy, Anita, Di Paolo, Julie, Lee, Hank, He, Joyce, Hu, Jing, Dreiling, Lyndah K., Friedberg, Jonathan W.
Publicado no Blood (2016)

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis

Por Katewa, Arna, Wang, Yugang, Hackney, Jason A., Huang, Tao, Suto, Eric, Ramamoorthi, Nandhini, Austin, Cary D., Bremer, Meire, Chen, Jacob Zhi, Crawford, James J., Currie, Kevin S., Blomgren, Peter, DeVoss, Jason, DiPaolo, Julie A., Hau, Jonathan, Johnson, Adam, Lesch, Justin, DeForge, Laura E., Lin, Zhonghua, Liimatta, Marya, Lubach, Joseph W., McVay, Sami, Modrusan, Zora, Nguyen, Allen, Poon, Chungkee, Wang, Jianyong, Liu, Lichuan, Lee, Wyne P., Wong, Harvey, Young, Wendy B., Townsend, Michael J., Reif, Karin
Publicado no JCI Insight (2017)

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

Por Wang, Xiaojing, Barbosa, James, Blomgren, Peter, Bremer, Meire C., Chen, Jacob, Crawford, James J., Deng, Wei, Dong, Liming, Eigenbrot, Charles, Gallion, Steve, Hau, Jonathon, Hu, Huiyong, Johnson, Adam R., Katewa, Arna, Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Mitchell, Scott A., Ortwine, Daniel F., DiPaolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Zhao, Zhongdong, Zhou, Fusheng, Currie, Kevin S., Young, Wendy B.
Publicado no ACS Med Chem Lett (2017)