PI3K/Akt promotes feedforward mTORC2 activation through IKKα

Por Dan, Han C., Antonia, Ricardo J., Baldwin, Albert S.
Publicado no Oncotarget (2016)

Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)

Por Dan, Han C., Ebbs, Aaron, Pasparakis, Manolis, Van Dyke, Terry, Basseres, Daniela S., Baldwin, Albert S.
Publicado em 2014

Identification of Akt Interaction Protein PHF20/TZP That Transcriptionally Regulates p53

Por Park, Sungman, Kim, Donghwa, Dan, Han C., Chen, Huihua, Testa, Joseph R., Cheng, Jin Q.
Publicado em 2012

IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer

Por Li, Zhipeng, Yang, Zejia, Lapidus, Rena G, Liu, Xuefeng, Cullen, Kevin J, Dan, Han C
Publicado no Am J Cancer Res (2015)

Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.

Por Park, Sungman, Kim, Donghwa, Dan, Han C., Chen, Huihua, Testa, Joseph R., Cheng, Jin Q.
Publicado no J Biol Chem (2016)

Differential IKK/NF-κB Activity is Mediated by TSC2 through mTORC1 in PTEN-null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells

Por Gao, Yu, Gartenhaus, Ronald B., Lapidus, Rena G., Hussain, Arif, Zhang, Yanting, Wang, Xinghuan, Dan, Han C.
Publicado no Mol Cancer Res (2015)

A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-κB regulates head and neck squamous cell carcinoma proliferation

Por Li, Zhipeng, Yang, Zejia, Passaniti, Antonino, Lapidus, Rena G., Liu, Xuefeng, Cullen, Kevin J., Dan, Han C.
Publicado no Oncotarget (2016)

Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK

Por Dan, Han C., Cooper, Matthew J., Cogswell, Patricia C., Duncan, Joseph A., Ting, Jenny P.-Y., Baldwin, Albert S.
Publicado em 2008

Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and Treg cell function via modulating mTOR pathway

Por Zhao, Yan G., Wang, Yunqi, Guo, Zengli, Gu, Ai-di, Dan, Han C., Baldwin, Albert S., Hao, Weidong, Wan, Yisong Y.
Publicado em 2012

Targeting IκB kinase β/NF-κB signaling in human prostate cancer by a novel IκB kinase β inhibitor CmpdA

Por Zhang, Yanting, Lapidus, Rena G., Liu, Peiyan, Choi, Eun Yong, Adediran, Samusi, Hussain, Arif, Wang, Xinghuan, Liu, Xuefeng, Dan, Han C.
Publicado no Mol Cancer Ther (2016)

Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway

Por Wang, Gang, Cao, Rui, Wang, Yongzhi, Qian, Guofeng, Dan, Han C., Jiang, Wei, Ju, Lingao, Wu, Min, Xiao, Yu, Wang, Xinghuan
Publicado no Sci Rep (2016)

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

Por Dan, Han C., Sun, Mei, Kaneko, Satoshi, Feldman, Richard I., Nicosia, Santo V., Wang, Hong-Gang, Tsang, Benjamin K., Cheng, Jin Q.
Publicado no J Biol Chem (2016)

Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop

Por Cao, Rui, Wang, Gang, Qian, Kaiyu, Chen, Liang, Qian, Guofeng, Xie, Conghua, Dan, Han C., Jiang, Wei, Wu, Min, Wu, Chin-Lee, Xiao, Yu, Wang, Xinghuan
Publicado no J Cancer (2017)

Identification and Characterization of Putative Tumor Suppressor NGB, a GTP-Binding Protein That Interacts with the Neurofibromatosis 2 Protein

Por Lee, Hansoo, Kim, Donghwa, Dan, Han C., Wu, Eric L., Gritsko, Tatiana M., Cao, Chuanhai, Nicosia, Santo V., Golemis, Erica A., Liu, Wanguo, Coppola, Domenico, Brem, Steven S., Testa, Joseph R., Cheng, Jin Q.
Publicado em 2007

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.

Por Dan, Han C., Sun, Mei, Yang, Lin, Feldman, Richard I., Sui, Xue-Mei, Ou, Chien Chen, Nellist, Mark, Yeung, Raymond S., Halley, Dicky J. J., Nicosia, Santo V., Pledger, Warren J., Cheng, Jin Q.
Publicado no J Biol Chem (2016)

Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer

Por Timofeeva, Olga A., Palechor-Ceron, Nancy, Li, Guanglei, Yuan, Hang, Krawczyk, Ewa, Zhong, Xiaogang, Liu, Geng, Upadhyay, Geeta, Dakic, Aleksandra, Yu, Songtao, Fang, Shuang, Choudhury, Sujata, Zhang, Xueping, Ju, Andrew, Lee, Myeong-Seon, Dan, Han C., Ji, Youngmi, Hou, Yong, Zheng, Yun-Ling, Albanese, Chris, Rhim, Johng, Schlegel, Richard, Dritschilo, Anatoly, Liu, Xuefeng
Publicado no Oncotarget (2016)